Synthesis, acid-base properties and hydrogel formation studies of a bisquinoline based low molecular weight gelator
View/ Open
Metadata
Show full item recordcomunitat-uji-handle:10234/158176
comunitat-uji-handle2:10234/71324
comunitat-uji-handle3:10234/98504
comunitat-uji-handle4:
TFG-TFMMetadata
Title
Synthesis, acid-base properties and hydrogel formation studies of a bisquinoline based low molecular weight gelatorAuthor (s)
Tutor/Supervisor; University.Department
Miravet Celades, Juan Felipe; Universitat Jaume I. Departament de Química Inorgànica i OrgànicaDate
2018-07Publisher
Universitat Jaume IAbstract
The research group, where this final degree project was carried out, was
interested in the use of molecule QVal3 (see structure below) as a hydrogelator
which could be used for entrapment and release of bioactive ... [+]
The research group, where this final degree project was carried out, was
interested in the use of molecule QVal3 (see structure below) as a hydrogelator
which could be used for entrapment and release of bioactive substances and for
the preparation of nano/microparticles. This compound is related to previouslyl
reported structures prepared in the group. As a first step towards that goal, this
project aims to optimize the synthetic preparation of QVal3 and study its hydrogel
formation properties.12, 13
In detail the objectives are the following:
i. The synthesis and characterization of QVal3. In particular, optimization of
the amide formation step implied in its preparation.
ii. Determination of the minimum gelator concentration in aqueous media
and evaluation of the influence of the concentration of DMSO present, in
a small proportion due to gel preparation procedure, on the gelation
efficiency.
iii. Evaluation of the acid-base constants of QVal3 to assess the range of pH
where the molecule is neutral and prone to aggregation. Likewise, the
influence of different amounts of DMSO in the aqueous system on pKa
values will be tested. [-]
Description
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2017/2018
Type
info:eu-repo/semantics/bachelorThesisRights
info:eu-repo/semantics/openAccess
This item appears in the folowing collection(s)
- Grau en Química [265]
The following license files are associated with this item: