Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury
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INVESTIGACIONMetadades
Títol
Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain InjuryAutoria
Data de publicació
2018-01-04Editor
ElsevierISSN
1934-5909; 1875-9777Cita bibliogràfica
JINNOU, Hideo, et al. Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury. Cell Stem Cell, 2018, vol. 22, no 1, p. 128-137Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30457-5Versió
info:eu-repo/semantics/submittedVersionParaules clau / Matèries
Resum
Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon ... [+]
Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during post-natal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-containing scaffold into injured neonatal brains likewise promotes migration and maturation of V-SVZ-derived neuroblasts, leading to functional improvements in impaired gait behaviors. Together these results suggest that RG fibers enable postnatal V-SVZ-derived neuroblasts to migrate toward sites of injury, thereby enhancing neuronal regeneration and functional recovery from neonatal brain injuries. [-]
Publicat a
Cell Stem Cell, 2018, vol. 22, no 1Proyecto de investigación
Bilateral Open Partnership Joint Research Projects; JSPS KAKENHI: 26250019, 17H01392, 17K18007; Nagoya City University; Terumo Foundation for Life Sciences and Arts; JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers: S2704; MEXT KAKENHI: 22122004, 17H05750, 17H05512; NEXT: LS104; Takeda Science FoundationDrets d'accés
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