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Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury
dc.contributor.author | Jinnou, Hideo | |
dc.contributor.author | Sawada, Masato | |
dc.contributor.author | Kawase, Koya | |
dc.contributor.author | Kaneko, Naoko | |
dc.contributor.author | Herranz-Pérez, Vicente | |
dc.contributor.author | Miyamoto, Takuya | |
dc.contributor.author | Kawaue, Takumi | |
dc.contributor.author | Miyata, Takaki | |
dc.contributor.author | Tabata, Yasuhiko | |
dc.contributor.author | Akaike, Toshihiro | |
dc.contributor.author | García-Verdugo, Jose Manuel | |
dc.contributor.author | Ajioka, Itsuki | |
dc.contributor.author | Saitoh, Shinji | |
dc.contributor.author | Sawamoto, Kazunobu | |
dc.date.accessioned | 2018-05-08T11:09:06Z | |
dc.date.available | 2018-05-08T11:09:06Z | |
dc.date.issued | 2018-01-04 | |
dc.identifier.citation | JINNOU, Hideo, et al. Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury. Cell Stem Cell, 2018, vol. 22, no 1, p. 128-137 | ca_CA |
dc.identifier.issn | 1934-5909 | |
dc.identifier.issn | 1875-9777 | |
dc.identifier.uri | http://hdl.handle.net/10234/174569 | |
dc.description.abstract | Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during post-natal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-containing scaffold into injured neonatal brains likewise promotes migration and maturation of V-SVZ-derived neuroblasts, leading to functional improvements in impaired gait behaviors. Together these results suggest that RG fibers enable postnatal V-SVZ-derived neuroblasts to migrate toward sites of injury, thereby enhancing neuronal regeneration and functional recovery from neonatal brain injuries. | ca_CA |
dc.format.extent | 10 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Cell Stem Cell, 2018, vol. 22, no 1 | ca_CA |
dc.rights | Copyright © Elsevier Inc. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | neonatal brain injury | ca_CA |
dc.subject | postnatal neurogenesis | ca_CA |
dc.subject | ventricular-subventricular zone | ca_CA |
dc.subject | radial glial cell | ca_CA |
dc.subject | neuronal migration | ca_CA |
dc.subject | neuronal regeneration | ca_CA |
dc.subject | gait behavior | ca_CA |
dc.subject | N-cadherin | ca_CA |
dc.title | Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.stem.2017.11.005 | |
dc.relation.projectID | Bilateral Open Partnership Joint Research Projects; JSPS KAKENHI: 26250019, 17H01392, 17K18007; Nagoya City University; Terumo Foundation for Life Sciences and Arts; JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers: S2704; MEXT KAKENHI: 22122004, 17H05750, 17H05512; NEXT: LS104; Takeda Science Foundation | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30457-5 | ca_CA |
dc.contributor.funder | We thank M. Yamaguchi, S. Itohara, T. Ikeda, R. Kageyama, and the MMRRC for transgenic mouse lines; K. Yoshikawa and T. Seki for antibodies; T. Kawauchi, R.L. Huganir, M. Matsuda, K. Kaibuchi, and M. Gotz for plasmids; S. Yamagishi, A. Alvarez-Buylla, L. Fuentealba, H. Takase, I. Miyoshi, and T. Miyamoto for technical support; and Sawamoto laboratory members for discussions. This work was supported by research grants from NEXT (LS104 to KS.), MEXT KAKENHI (22122004, 17H05750, and 17H05512 to KS.), JSPS KAKENHI (26250019 and 17H01392 to K.S. and 17K18007 to H.J.), Bilateral Open Partnership Joint Research Projects (to KS.), the JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers (S2704 to M.S., N.K., and KS.), Terumo Foundation for Life Sciences and Arts (to I.A. and KS.), Grant-in-Aid for Research at Nagoya City University (to KS.), and the Takeda Science Foundation (to KS.) | ca_CA |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
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