Peptide-Based Molecular Hydrogels as Supramolecular Protein Mimics
Impact
Scholar |
Other documents of the author: Singh, Nishant; Kumar, Mohit; Miravet, Juan; Escuder, Beatriu
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
comunitat-uji-handle4:
INVESTIGACIONThis resource is restricted
http://dx.doi.org/10.1002/chem.201602624 |
Metadata
Title
Peptide-Based Molecular Hydrogels as Supramolecular Protein MimicsDate
2017-01-23Publisher
WileyISSN
0947-6539; 1521-3765Bibliographic citation
SINGH, Nishant, et al. Peptide‐Based Molecular Hydrogels as Supramolecular Protein Mimics. Chemistry-A European Journal, 2017, vol. 23, no 5, p. 981-993.Type
info:eu-repo/semantics/articlePublisher version
http://onlinelibrary.wiley.com/doi/10.1002/chem.201602624/fullVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
This Minireview concerns recent advances in the design, synthesis, and application of low molecular-weight peptidic hydrogelators. The sequence-specific combinations of amino acid side chain functionalities combined ... [+]
This Minireview concerns recent advances in the design, synthesis, and application of low molecular-weight peptidic hydrogelators. The sequence-specific combinations of amino acid side chain functionalities combined with hydrogen bonding of amide backbones and hydrophobic (aromatic) capping groups give these peptidic molecules the intrinsic tendency to self-assemble. The most prevalent designs include N-capped amino acid residues, bolamphiphilic peptides, and amphipathic peptides. Factors such as hydrophobic effects, the Hofmeister effect, and tunable ionization influence their aggregation properties. The self-assembly of simple bio-inspired building blocks into higher organized structures allows comparisons to be drawn with proteins and their complex functionalities, providing preliminary insights into complex biological functions and also enabling their application in a wide range of fields including catalysis, biomedical applications, and mimicry of natural dissipative systems. The Minireview is concluded by a short summary and outlook, highlighting the advances and steps required to bridge the gaps in the understanding of such systems. [-]
Is part of
Chemistry-A European Journal, 2017, vol. 23, no 5, p. 981-993Investigation project
Ministry of Science and Innovation of Spain / CTQ2012-37735 ; Universitat Jaume I / P1.1B2012-25Rights
Copyright © John Wiley & Sons, Inc. All Rights Reserved
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
This item appears in the folowing collection(s)
- QFA_Articles [829]