Peptide-Based Molecular Hydrogels as Supramolecular Protein Mimics
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Scholar |
Altres documents de l'autoria: Singh, Nishant; Kumar, Mohit; Miravet, Juan; Escuder, Beatriu
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http://dx.doi.org/10.1002/chem.201602624 |
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Títol
Peptide-Based Molecular Hydrogels as Supramolecular Protein MimicsData de publicació
2017-01-23Editor
WileyISSN
0947-6539; 1521-3765Cita bibliogràfica
SINGH, Nishant, et al. Peptide‐Based Molecular Hydrogels as Supramolecular Protein Mimics. Chemistry-A European Journal, 2017, vol. 23, no 5, p. 981-993.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://onlinelibrary.wiley.com/doi/10.1002/chem.201602624/fullVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
This Minireview concerns recent advances in the design, synthesis, and application of low molecular-weight peptidic hydrogelators. The sequence-specific combinations of amino acid side chain functionalities combined ... [+]
This Minireview concerns recent advances in the design, synthesis, and application of low molecular-weight peptidic hydrogelators. The sequence-specific combinations of amino acid side chain functionalities combined with hydrogen bonding of amide backbones and hydrophobic (aromatic) capping groups give these peptidic molecules the intrinsic tendency to self-assemble. The most prevalent designs include N-capped amino acid residues, bolamphiphilic peptides, and amphipathic peptides. Factors such as hydrophobic effects, the Hofmeister effect, and tunable ionization influence their aggregation properties. The self-assembly of simple bio-inspired building blocks into higher organized structures allows comparisons to be drawn with proteins and their complex functionalities, providing preliminary insights into complex biological functions and also enabling their application in a wide range of fields including catalysis, biomedical applications, and mimicry of natural dissipative systems. The Minireview is concluded by a short summary and outlook, highlighting the advances and steps required to bridge the gaps in the understanding of such systems. [-]
Publicat a
Chemistry-A European Journal, 2017, vol. 23, no 5, p. 981-993Proyecto de investigación
Ministry of Science and Innovation of Spain / CTQ2012-37735 ; Universitat Jaume I / P1.1B2012-25Drets d'accés
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