Peptide-Based Molecular Hydrogels as Supramolecular Protein Mimics
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Scholar |
Otros documentos de la autoría: Singh, Nishant; Kumar, Mohit; Miravet, Juan; Escuder, Beatriu
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http://dx.doi.org/10.1002/chem.201602624 |
Metadatos
Título
Peptide-Based Molecular Hydrogels as Supramolecular Protein MimicsFecha de publicación
2017-01-23Editor
WileyISSN
0947-6539; 1521-3765Cita bibliográfica
SINGH, Nishant, et al. Peptide‐Based Molecular Hydrogels as Supramolecular Protein Mimics. Chemistry-A European Journal, 2017, vol. 23, no 5, p. 981-993.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://onlinelibrary.wiley.com/doi/10.1002/chem.201602624/fullVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
This Minireview concerns recent advances in the design, synthesis, and application of low molecular-weight peptidic hydrogelators. The sequence-specific combinations of amino acid side chain functionalities combined ... [+]
This Minireview concerns recent advances in the design, synthesis, and application of low molecular-weight peptidic hydrogelators. The sequence-specific combinations of amino acid side chain functionalities combined with hydrogen bonding of amide backbones and hydrophobic (aromatic) capping groups give these peptidic molecules the intrinsic tendency to self-assemble. The most prevalent designs include N-capped amino acid residues, bolamphiphilic peptides, and amphipathic peptides. Factors such as hydrophobic effects, the Hofmeister effect, and tunable ionization influence their aggregation properties. The self-assembly of simple bio-inspired building blocks into higher organized structures allows comparisons to be drawn with proteins and their complex functionalities, providing preliminary insights into complex biological functions and also enabling their application in a wide range of fields including catalysis, biomedical applications, and mimicry of natural dissipative systems. The Minireview is concluded by a short summary and outlook, highlighting the advances and steps required to bridge the gaps in the understanding of such systems. [-]
Publicado en
Chemistry-A European Journal, 2017, vol. 23, no 5, p. 981-993Proyecto de investigación
Ministry of Science and Innovation of Spain / CTQ2012-37735 ; Universitat Jaume I / P1.1B2012-25Derechos de acceso
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