Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage
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Altres documents de l'autoria: Almansa, Inmaculada; Barcia, Jorge M; López-Pedrajas, Rosa; Muriach, Maria; Miranda, María; Romero, Francisco J.
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comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative DamageAutoria
Data de publicació
2013Editor
Hindawi Publishing CorporationISSN
1942-0900; 1942-0994Cita bibliogràfica
Inmaculada Almansa, Jorge M. Barcia, Rosa López-Pedrajas, María Muriach, María Miranda, and Francisco Javier Romero, “Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 296898, 5 pages, 2013. doi:10.1155/2013/296898Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.hindawi.com/journals/omcl/2013/296898/Versió
info:eu-repo/semantics/publishedVersionResum
Naltrexone, an antagonist of 𝜇�-opioid receptors, is clinically used as adjuvant therapy of alcohol dishabituation. The aim of
the present work was to test the effect of 1 mg/kg body weight of naltrexone to revert ... [+]
Naltrexone, an antagonist of 𝜇�-opioid receptors, is clinically used as adjuvant therapy of alcohol dishabituation. The aim of
the present work was to test the effect of 1 mg/kg body weight of naltrexone to revert oxidative stress-related biochemical
alterations, in the hippocampus and serum of chronic alcoholic adult rats. Malondialdehyde concentration was increased and
glutathione peroxidase activity was decreased in hippocampus and serum of alcohol-treated rats. Naltrexone treatment restored
these alterations. The in vitro antioxidant ability of Ntx could not justify these effects considering the doses used. Thus this apparent
protective effect of Ntx can only be attributed to its pharmacological effects, as herein discussed. [-]
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Oxidative Medicine and Cellular Longevity Volume 2013 (2013), Article ID 296898Drets d'accés
info:eu-repo/semantics/openAccess
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Except where otherwise noted, this item's license is described as Copyright © 2013 Inmaculada Almansa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.