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Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage
dc.contributor.author | Almansa, Inmaculada | |
dc.contributor.author | Barcia, Jorge M | |
dc.contributor.author | López-Pedrajas, Rosa | |
dc.contributor.author | Muriach, Maria | |
dc.contributor.author | Miranda, María | |
dc.contributor.author | Romero, Francisco J. | |
dc.date.accessioned | 2017-07-27T11:20:03Z | |
dc.date.available | 2017-07-27T11:20:03Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Inmaculada Almansa, Jorge M. Barcia, Rosa López-Pedrajas, María Muriach, María Miranda, and Francisco Javier Romero, “Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 296898, 5 pages, 2013. doi:10.1155/2013/296898 | ca_CA |
dc.identifier.issn | 1942-0900 | |
dc.identifier.issn | 1942-0994 | |
dc.identifier.uri | http://hdl.handle.net/10234/168417 | |
dc.description.abstract | Naltrexone, an antagonist of 𝜇�-opioid receptors, is clinically used as adjuvant therapy of alcohol dishabituation. The aim of the present work was to test the effect of 1 mg/kg body weight of naltrexone to revert oxidative stress-related biochemical alterations, in the hippocampus and serum of chronic alcoholic adult rats. Malondialdehyde concentration was increased and glutathione peroxidase activity was decreased in hippocampus and serum of alcohol-treated rats. Naltrexone treatment restored these alterations. The in vitro antioxidant ability of Ntx could not justify these effects considering the doses used. Thus this apparent protective effect of Ntx can only be attributed to its pharmacological effects, as herein discussed. | ca_CA |
dc.description.sponsorShip | Ministerio de Educacion y Ciencia SAF2010-21317 Universidad Catolica de Valencia "San Vicente Martir" 2012-029-001 Plan Nacional sobre Drogas 2010/059 AI/ICB-Santander 07/12 | ca_CA |
dc.format.extent | 6 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Hindawi Publishing Corporation | ca_CA |
dc.relation.isPartOf | Oxidative Medicine and Cellular Longevity Volume 2013 (2013), Article ID 296898 | ca_CA |
dc.rights | Copyright © 2013 Inmaculada Almansa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.title | Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1155/2013/296898 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.hindawi.com/journals/omcl/2013/296898/ | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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Excepto si se señala otra cosa, la licencia del ítem se describe como: Copyright © 2013 Inmaculada Almansa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.