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Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts
dc.contributor.author | Rosell Negre, Patricia | |
dc.contributor.author | Bustamante, Juan Carlos | |
dc.contributor.author | Fuentes-Claramonte, Paola | |
dc.contributor.author | Costumero, Víctor | |
dc.contributor.author | Llopis Llácer, Juan José | |
dc.contributor.author | Barrós-Loscertales, Alfonso | |
dc.date.accessioned | 2017-05-02T09:54:01Z | |
dc.date.available | 2017-05-02T09:54:01Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Rosell-Negre P, Bustamante J-C, Fuentes-Claramonte P, Costumero V, Llopis-Llacer J-J, Barro´s-Loscertales A (2016) Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts. PLoS ONE 11(12): e0167400. doi:10.1371/journal.pone.0167400 | ca_CA |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10234/167331 | |
dc.description.abstract | The dopaminergic system provides the basis for the interaction between motivation and cognition. It is triggered by the possibility of obtaining rewards to initiate the neurobehavioral adaptations necessary to achieve them by directing the information from motivational circuits to cognitive and action circuits. In drug addiction, the altered dopamine (DA) modulation of the meso-cortico-limbic reward circuitry, such as the prefrontal cortex (PFC), underlies the disproportionate motivational value of drug use at the expense of other nondrug reinforcers and the user’s loss of control over his/her drug intake. We examine how the magnitude of the reward affects goal-directed processes in healthy control (HC) subjects and abstinent cocaine dependent (ACD) patients by using functional magnetic resonance imaging (fMRI) during a counting Stroop task with blocked levels of monetary incentives of different magnitudes (€0, €0.01, €0.5, €1 or €1.5). Our results showed that increasing reward magnitude enhances (1) performance facilitation in both groups; (2) left dorsolateral prefrontal cortex (DLPFC) activity in HC and left superior occipital cortex activity in ACD; and (3) left DLPFC and left putamen connectivity in ACD compared to HC. Moreover, we observed that (4) dorsal striatal and pallidum activity was associated with craving and addiction severity during the parametric increases in the monetary reward. In conclusion, the brain response to gradients in monetary value was different in HC and ACD, but both groups showed improved task performance due to the possibility of obtaining greater monetary rewards. | ca_CA |
dc.description.sponsorShip | This research has been supported by Grants PSI2012-33054 from the Spanish Ministry of Economy and Competitiveness (http://www.mineco.gob.es/), and by 2011I040 from the Spanish National Drug Strategy (http://www.pnsd.msssi.gob.es/) to ABL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ca_CA |
dc.format.extent | 22 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Public Library of Science | ca_CA |
dc.relation.isPartOf | PLoS ONE 11 (12) 2016 | ca_CA |
dc.rights | © 2016 Rosell-Negre et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ca_CA |
dc.rights | Atribución 4.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.title | Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0167400 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167400 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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