Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts
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Other documents of the author: Rosell Negre, Patricia; Bustamante, Juan Carlos; Fuentes-Claramonte, Paola; Costumero, Víctor; Llopis Llácer, Juan José; Barrós-Loscertales, Alfonso
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comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine AddictsAuthor (s)
Date
2016Publisher
Public Library of ScienceISSN
1932-6203Bibliographic citation
Rosell-Negre P, Bustamante J-C, Fuentes-Claramonte P, Costumero V, Llopis-Llacer J-J, Barro´s-Loscertales A (2016) Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts. PLoS ONE 11(12): e0167400. doi:10.1371/journal.pone.0167400Type
info:eu-repo/semantics/articlePublisher version
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167400Version
info:eu-repo/semantics/publishedVersionAbstract
The dopaminergic system provides the basis for the interaction between motivation and
cognition. It is triggered by the possibility of obtaining rewards to initiate the neurobehavioral
adaptations necessary to achieve ... [+]
The dopaminergic system provides the basis for the interaction between motivation and
cognition. It is triggered by the possibility of obtaining rewards to initiate the neurobehavioral
adaptations necessary to achieve them by directing the information from motivational circuits
to cognitive and action circuits. In drug addiction, the altered dopamine (DA) modulation
of the meso-cortico-limbic reward circuitry, such as the prefrontal cortex (PFC),
underlies the disproportionate motivational value of drug use at the expense of other nondrug
reinforcers and the user’s loss of control over his/her drug intake. We examine how the
magnitude of the reward affects goal-directed processes in healthy control (HC) subjects
and abstinent cocaine dependent (ACD) patients by using functional magnetic resonance
imaging (fMRI) during a counting Stroop task with blocked levels of monetary incentives of
different magnitudes (€0, €0.01, €0.5, €1 or €1.5). Our results showed that increasing
reward magnitude enhances (1) performance facilitation in both groups; (2) left dorsolateral
prefrontal cortex (DLPFC) activity in HC and left superior occipital cortex activity in ACD;
and (3) left DLPFC and left putamen connectivity in ACD compared to HC. Moreover, we
observed that (4) dorsal striatal and pallidum activity was associated with craving and addiction
severity during the parametric increases in the monetary reward. In conclusion, the
brain response to gradients in monetary value was different in HC and ACD, but both groups
showed improved task performance due to the possibility of obtaining greater monetary
rewards. [-]
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