Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial
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http://dx.doi.org/10.1002/clc.22555 |
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Title
Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled TrialAuthor (s)
Date
2016-08-02Publisher
WileyBibliographic citation
PALAU SAMPIO, Patricia; DOMÍMNGUEZ MAFÉ, Eloy; LÓPEZ, Laura; HEREDIA, Raquel; GONZÁLEZ, Jessika; RAMÓN, José María; SERRA, Pilar; SANTAS, Enrique; BODÍ, Vicent; SANCHIS, Juan; CHORRO, Francisco J.; NÚÑEZ, Julio. nspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial. Clinical Cardiology (2016), v. 39, p. 8, pp. 433-439Type
info:eu-repo/semantics/articlePublisher version
http://onlinelibrary.wiley.com/doi/10.1002/clc.22555/abstract;jsessionid=9DED582 ...Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent form of heart failure
in developed countries. Regrettably, there is no evidence-based effective therapy for HFpEF. We seek to
ev ... [+]
Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent form of heart failure
in developed countries. Regrettably, there is no evidence-based effective therapy for HFpEF. We seek to
evaluate whether inspiratory muscle training, functional electrical stimulation, or a combination of both can
improve exercise capacity as well as left ventricular diastolic function, biomarker profile, quality of life (QoL),
and prognosis in patients with HFpEF. A total of 60 stable symptomatic patients with HFpEF (New York
Heart Association class II–III/IV) will be randomized (1:1:1:1) to receive a 12-week program of inspiratory
muscle training, functional electrical stimulation, a combination of both, or standard care alone. The primary
endpoint of the study is change in peak exercise oxygen uptake; secondary endpoints are changes in QoL,
echocardiogram parameters, and prognostic biomarkers. As of March 21, 2016, thirty patients have been
enrolled. Searching for novel therapies that improve QoL and autonomy in the elderly with HFpEF has become
a health care priority. We believe that this study will add important knowledge about the potential utility of 2
simple and feasible physical interventions for the treatment of advanced HFpEF. [-]
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Clinical Cardiology (2016), v. 39, p. 8Rights
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