Increased regional gray matter atrophy and enhanced functional connectivy in male multiple sclerosis patients
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Otros documentos de la autoría: Sanchis-Segura, Carla; Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; Fittipaldi Márquez, María Sol; Avila, Cesar; Forn, Cristina
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
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comunitat-uji-handle3:10234/8636
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Título
Increased regional gray matter atrophy and enhanced functional connectivy in male multiple sclerosis patientsAutoría
Fecha de publicación
2016-09Editor
ElsevierCita bibliográfica
SANCHIS-SEGURA, C., et al. Increased regional gray matter atrophy and enhanced functional connectivity in male multiple sclerosis patients. Neuroscience Letters, 2016, vol. 630, p. 154-157.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0304394016305225Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
Evidence suggests that sex/gender is an important factor for understanding multiple sclerosis (MS) and that some of its neuropathological consequences might manifest earlier in males. In the present study, we assessed ... [+]
Evidence suggests that sex/gender is an important factor for understanding multiple sclerosis (MS) and that some of its neuropathological consequences might manifest earlier in males. In the present study, we assessed gray matter (GM) volume and functional connectivity (FC) in a sample of female and male MS patients (MSp) and female and male healthy controls (HCs). As compared to female MSp, male MSp showed decreased GM volume in the bilateral frontal areas and increased FC between different brain regions. Because both sets of changes correlated significantly and no differences in cognitive performance were observed, we suggest that the FC increase observed in male MSp acts as a compensatory mechanism for their more extensive GM loss and that it promotes a functional convergence between male- and female-MSp. [-]
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Neuroscience Letters Volume 630, September 2016Derechos de acceso
© 2016 Elsevier Ireland Ltd. All rights reserved.
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info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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