Increased regional gray matter atrophy and enhanced functional connectivy in male multiple sclerosis patients
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
Increased regional gray matter atrophy and enhanced functional connectivy in male multiple sclerosis patientsAuthor (s)
Date
2016-09Publisher
ElsevierBibliographic citation
SANCHIS-SEGURA, C., et al. Increased regional gray matter atrophy and enhanced functional connectivity in male multiple sclerosis patients. Neuroscience Letters, 2016, vol. 630, p. 154-157.Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0304394016305225Version
info:eu-repo/semantics/submittedVersionSubject
Abstract
Evidence suggests that sex/gender is an important factor for understanding multiple sclerosis (MS) and that some of its neuropathological consequences might manifest earlier in males. In the present study, we assessed ... [+]
Evidence suggests that sex/gender is an important factor for understanding multiple sclerosis (MS) and that some of its neuropathological consequences might manifest earlier in males. In the present study, we assessed gray matter (GM) volume and functional connectivity (FC) in a sample of female and male MS patients (MSp) and female and male healthy controls (HCs). As compared to female MSp, male MSp showed decreased GM volume in the bilateral frontal areas and increased FC between different brain regions. Because both sets of changes correlated significantly and no differences in cognitive performance were observed, we suggest that the FC increase observed in male MSp acts as a compensatory mechanism for their more extensive GM loss and that it promotes a functional convergence between male- and female-MSp. [-]
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Neuroscience Letters Volume 630, September 2016Rights
© 2016 Elsevier Ireland Ltd. All rights reserved.
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