Research of antitumoral compounds

Abstract

The main idea is to explore colchicine derivatives as potential inhibitors of cellular division. It has been explained that colchicine is an antimitotic compound which stops or inhibits the cellular division. The main problem is that colchicine has a narrow therapeutic margin, which means that efficient and toxic doses are very similar.

This research line is focused in the developing derivatives of colchicine with better therapeutic margin and improved antitumor activity. In addition, more tests are going to be carried out in order to determine if these new compounds have inhibition abilities over certain genes related to cancer activities. In this case, modifications over the acetamide group of the colchicine are going to be carried and it is going to be substituted with different regioisomers of chlorobenzoic acid. Hence, the objectives are: Synthesis of colchicine derivatives from 2-, 3-, and 4-chlorobenzoic acid. Evaluation of the biological activity of synthesized compounds.