Research of antitumoral compounds
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/158176
comunitat-uji-handle2:10234/71324
comunitat-uji-handle3:10234/98162
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Títol
Research of antitumoral compoundsAutoria
Tutor/Supervisor
Falomir Ventura, EvaTutor/Supervisor; Universitat.Departament
Universitat Jaume I. Departament de Química Inorgànica i OrgànicaData de publicació
2014Editor
Universitat Jaume IResum
The main idea is to explore colchicine derivatives as potential inhibitors of cellular
division. It has been explained that colchicine is an antimitotic compound which stops
or inhibits the cellular division. The ... [+]
The main idea is to explore colchicine derivatives as potential inhibitors of cellular
division. It has been explained that colchicine is an antimitotic compound which stops
or inhibits the cellular division. The main problem is that colchicine has a narrow
therapeutic margin, which means that efficient and toxic doses are very similar.
This research line is focused in the developing derivatives of colchicine with
better therapeutic margin and improved antitumor activity. In addition, more tests
are going to be carried out in order to determine if these new compounds have
inhibition abilities over certain genes related to cancer activities. In this case,
modifications over the acetamide group of the colchicine are going to be carried and
it is going to be substituted with different regioisomers of chlorobenzoic acid. Hence,
the objectives are: Synthesis of colchicine derivatives from 2-, 3-, and 4-chlorobenzoic acid. Evaluation of the biological activity of synthesized compounds. [-]
Paraules clau / Matèries
Descripció
Treball Final de Grau en Química. Codi: QU0943. Curs: 2014/2015
Tipus de document
info:eu-repo/semantics/bachelorThesisDrets d'accés
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