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Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide

dc.contributor.authorFaggi, Enrico
dc.contributor.authorPérez, Yolanda
dc.contributor.authorLuis, Santiago V.
dc.contributor.authorAlfonso Rodríguez, Ignacio
dc.date.accessioned2016-06-14T09:04:33Z
dc.date.available2016-06-14T09:04:33Z
dc.date.issued2016-05
dc.identifier.citationFaggi, E., Pérez, Y., Luis, S. V., & Alfonso, I. (2016). Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide. Chemical Communications.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/160675
dc.description.abstractHere we report two new artificial pseudopeptidic cages that bind the EYE peptide epitope in pure water at physiological pH (as studied by fluorescence and NMR spectroscopies). The supramolecular complexation of the Tyr residues efficiently precludes their subsequent PTK-catalysed phosphorylation. Our results show a supramolecular modulation of the PTK activity by competitive substrate caging.ca_CA
dc.description.sponsorShipThis work was supported by MINECO/FEDER (CTQ2012-38543-C03, CTQ2015-68429-R and CTQ2015-70117-R projects) and Generalitat de Catalunya (AGAUR, 2014 SGR 231).ca_CA
dc.format.extent4 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.language.isodeuca_CA
dc.publisherRoyal Society of Chemistryca_CA
dc.relation.isPartOfChemical Communications, 2016, Advanced Articleca_CA
dc.rights© The Royal Society of Chemistry 2016ca_CA
dc.rightsAttribution-NonCommercial 4.0 Spain*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectpeptidesca_CA
dc.subjectartificial pseudopeptidic cagesca_CA
dc.subjectpure waterca_CA
dc.titleSupramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptideca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1039/C6CC03875A
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc03875a#!divAbstractca_CA


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