Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide
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Títol
Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptideData de publicació
2016-05Editor
Royal Society of ChemistryCita bibliogràfica
Faggi, E., Pérez, Y., Luis, S. V., & Alfonso, I. (2016). Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide. Chemical Communications.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc03875a#!divAbstractParaules clau / Matèries
Resum
Here we report two new artificial pseudopeptidic cages that bind the EYE peptide epitope in pure water at physiological pH (as studied by fluorescence and NMR spectroscopies). The supramolecular complexation of the ... [+]
Here we report two new artificial pseudopeptidic cages that bind the EYE peptide epitope in pure water at physiological pH (as studied by fluorescence and NMR spectroscopies). The supramolecular complexation of the Tyr residues efficiently precludes their subsequent PTK-catalysed phosphorylation. Our results show a supramolecular modulation of the PTK activity by competitive substrate caging. [-]
Publicat a
Chemical Communications, 2016, Advanced ArticleDrets d'accés
© The Royal Society of Chemistry 2016
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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