Highly sensitive and ultrafast read mapping for RNA-seq analysis
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7036
comunitat-uji-handle3:10234/8620
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INVESTIGACIONMetadata
Title
Highly sensitive and ultrafast read mapping for RNA-seq analysisAuthor (s)
Date
2016Publisher
Oxford University PressISSN
1340-2838; 1756-1663Bibliographic citation
I. Medina, J. Tárraga, H. Martínez, S. Barrachina, M. I. Castillo, J. Paschall, J. Salavert-Torres, I. Blanquer-Espert, V. Hernández-García, E. S. Quintana-Ortí, and J. Dopazo. Highly sensitive and ultrafast read mapping for RNA-seq analysis DNA Res first published online January 5, 2016 doi:10.1093/dnares/dsv039Type
info:eu-repo/semantics/articlePublisher version
http://dnaresearch.oxfordjournals.org/content/early/2016/01/05/dnares.dsv039.ful ...Subject
Abstract
As sequencing technologies progress, the amount of data produced grows exponentially, shifting
the bottleneck of discovery towards the data analysis phase. In particular, currently available mapping
solutions for ... [+]
As sequencing technologies progress, the amount of data produced grows exponentially, shifting
the bottleneck of discovery towards the data analysis phase. In particular, currently available mapping
solutions for RNA-seq leave room for improvement in terms of sensitivity and performance, hindering
an efficient analysis of transcriptomes by massive sequencing. Here, we present an
innovative approach that combines re-engineering, optimization and parallelization. This solution results
in a significant increase of mapping sensitivity over a wide range of read lengths and substantial
shorter runtimes when compared with current RNA-seq mapping methods available. [-]
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info:eu-repo/semantics/openAccess
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