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Fast gas chromatographic residue analysis in animal feed using split injection and atmospheric pressure chemical ionisation tandem mass spectrometry
dc.contributor.author | Tienstra, M. | |
dc.contributor.author | Portoles, Tania | |
dc.contributor.author | Hernandez, Felix | |
dc.contributor.author | Mol, Johannes G. J. | |
dc.date.accessioned | 2016-04-21T17:50:43Z | |
dc.date.available | 2016-04-21T17:50:43Z | |
dc.date.issued | 2015-11 | |
dc.identifier.issn | 0021-9673 | |
dc.identifier.uri | http://hdl.handle.net/10234/158914 | |
dc.description.abstract | Significant speed improvement for instrumental runtime would make GC–MS much more attractive for determination of pesticides and contaminants and as complementary technique to LC–MS. This was the trigger to develop a fast method (time between injections less than 10 min) for the determination of pesticides and PCBs that are not (or less) amenable to LC–MS. A key factor in achieving shorter analysis time was the use of split injection (1:10) which allowed the use of a much higher initial GC oven temperature. A shorter column (15 m), higher temperature ramp, and higher carrier gas flow rate (6 mL/min) further contributed to analysis-time reduction. Chromatographic resolution was slightly compromised but still well fit-for-purpose. Due to the high sensitivity of the technique used (GC–APCI-triple quadrupole MS/MS), quantification and identification were still possible down to the 10 μg/kg level, which was demonstrated by successful validation of the method for complex feed matrices according to EU guidelines. Other advantages of the method included a better compatibility of acetonitrile extracts (e.g. QuEChERS) with GC, and a reduced transfer of co-extractants into the GC column and mass spectrometer. | ca_CA |
dc.description.sponsorShip | We would like to acknowledge Jack Cochran from Restek for stimulating discussions on fast GC and inlet optimisation. The authors are grateful to Serveis Centrals d’Instrumentació Científica (SCIC), University Jaume I for the use of GC-Xevo TQ-S. The authors acknowledge the financial support of Generalitat Valenciana, as research group of excellence PROMETEO II/2014/023 and also for the development of the ISIC project on Collaborative Research on Environment and Food-Safety (ISIC/2012/016). The Dutch Ministry of Economic Affairs is acknowledged for financially supporting this work (WOT-02-001-017). | |
dc.format.extent | 10 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Journal of Chromatography A, 2015, vol. 1422 | ca_CA |
dc.rights | Copyright © 2015 Elsevier B.V. All rights reserved. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | Fast gas chromatography | ca_CA |
dc.subject | APCI | ca_CA |
dc.subject | Tandem mass spectrometry | ca_CA |
dc.subject | Animal feed | ca_CA |
dc.subject | Pesticides | ca_CA |
dc.subject | PCBs | ca_CA |
dc.title | Fast gas chromatographic residue analysis in animal feed using split injection and atmospheric pressure chemical ionisation tandem mass spectrometry | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.chroma.2015.10.032 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0021967315014909 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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