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Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release
dc.contributor.author | Mérida, S. | |
dc.contributor.author | Sancho Tello, M. | |
dc.contributor.author | Muriach Saurí, María | |
dc.contributor.author | Miranda, M. | |
dc.contributor.author | Navea, A. | |
dc.contributor.author | Bosch Morell, F. | |
dc.date.accessioned | 2015-01-26T08:26:30Z | |
dc.date.available | 2015-01-26T08:26:30Z | |
dc.date.issued | 2013-08 | |
dc.identifier.issn | 1071-5762 | |
dc.identifier.uri | http://hdl.handle.net/10234/113199 | |
dc.description.abstract | Infl ammation results in the production of free radicals. We evaluated the anti-infl ammatory and antioxidant capacity of lipoic acid in an experimental uveitis model upon a subcutaneous injection of endotoxin into Lewis rats. The role of oxidative stress in the endotoxin-induced uveitis model is well-known. Besides, the Th1 response classically performs a central part in the immunopathological process of experimental autoimmune uveitis. Exogenous sources of lipoic acid have been shown to exhibit antioxidant and anti-infl ammatory properties. Our results show that lipoic acid treatment plays a preventive role in endotoxin-induced oxidative stress at 24 h post-administration and reduced Th1 lymphocytes-related cytokines by approximately 50 – 60%. Simultaneously, lipoic acid treatment caused a signifi cant reduction in uveal histopathological grading and in the protein concentration in aqueous humors, but not in cellular infi ltration. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Informa HealthCare | ca_CA |
dc.relation.isPartOf | Free Radical Research, vol. 47, no. 8 , p. 593-601 | ca_CA |
dc.rights | © 2013 Informa UK, Ltd. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | lipoic acid | ca_CA |
dc.subject | uveitis | ca_CA |
dc.subject | cytokines | ca_CA |
dc.subject | Th1 lymphocytes | ca_CA |
dc.subject | Th2 lymphocytes | ca_CA |
dc.subject | antioxidant | ca_CA |
dc.title | Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.3109/10715762.2013.805882 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://informahealthcare.com/doi/abs/10.3109/10715762.2013.805882 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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