Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release
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Other documents of the author: Mérida, S.; Sancho Tello, M.; Muriach Saurí, María; Miranda, M.; Navea, A.; Bosch Morell, F.
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http://dx.doi.org/10.3109/10715762.2013.805882 |
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Title
Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines releaseAuthor (s)
Date
2013-08Publisher
Informa HealthCareISSN
1071-5762Type
info:eu-repo/semantics/articlePublisher version
http://informahealthcare.com/doi/abs/10.3109/10715762.2013.805882Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Infl ammation results in the production of free radicals. We evaluated the anti-infl ammatory and antioxidant capacity of lipoic acid in an
experimental uveitis model upon a subcutaneous injection of endotoxin into ... [+]
Infl ammation results in the production of free radicals. We evaluated the anti-infl ammatory and antioxidant capacity of lipoic acid in an
experimental uveitis model upon a subcutaneous injection of endotoxin into Lewis rats. The role of oxidative stress in the endotoxin-induced
uveitis model is well-known. Besides, the Th1 response classically performs a central part in the immunopathological process of experimental
autoimmune uveitis. Exogenous sources of lipoic acid have been shown to exhibit antioxidant and anti-infl ammatory properties. Our
results show that lipoic acid treatment plays a preventive role in endotoxin-induced oxidative stress at 24 h post-administration and reduced
Th1 lymphocytes-related cytokines by approximately 50 – 60%. Simultaneously, lipoic acid treatment caused a signifi cant reduction in uveal
histopathological grading and in the protein concentration in aqueous humors, but not in cellular infi ltration. [-]
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Free Radical Research, vol. 47, no. 8 , p. 593-601Rights
© 2013 Informa UK, Ltd.
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