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The role of genetic variability in the GABRA6, 5-HTT and BDNF genes in anxiety-related traits
dc.contributor.author | Villa Martín, Elena | |
dc.contributor.author | Ibáñez, Manuel I | |
dc.contributor.author | Ortet, Generós | |
dc.contributor.author | Arias, Barbara | |
dc.contributor.author | Aguilera, Mari | |
dc.contributor.author | Moya-Higueras, Jorge | |
dc.contributor.author | Sáiz Martínez, Pilar Alejandra | |
dc.contributor.author | García-Portilla González, María Paz, 1962- | |
dc.contributor.author | Bobes García, Julio | |
dc.contributor.author | Fañanás Saura, Lourdes | |
dc.date.accessioned | 2013-05-17T09:15:32Z | |
dc.date.available | 2013-05-17T09:15:32Z | |
dc.date.issued | 2012-03 | |
dc.identifier.uri | http://hdl.handle.net/10234/63933 | |
dc.description.abstract | Objective: The aims of this study were to test the individual association of the serotonin transporter gene (SLC6A4), the brain-derived neurotrophic factor gene (BDNF) and the GABAAα6 receptor subunit gene (GABRA6) with anxiety-related traits and to explore putative gene-gene interactions in a Spanish healthy sample. Method: A sample of 937 individuals from the general population completed the Temperament and Character Inventory questionnaire to explore Harm Avoidance (HA) dimension; a subsample of 553 individuals also filled in the Big Five Questionnaire to explore the Neuroticism dimension. The whole sample was genotyped for the 5-HTTLPR polymorphism (SLC6A4 gene), the Val66Met polymorphism (BDNF gene) and the T1521C polymorphism (GABRA6 gene). Results: Homozygous individuals for the T allele of the T1512C polymorphism presented slightly higher scores for HA than C allele carriers (F = 2.96, P = 0.019). In addition, there was a significant gene-gene interaction on HA between the 5-HTTLPR and Val66Met polymorphisms (F = 3.4, P = 0.009). Conclusion: GABRA6 emerges as a candidate gene involved in the variability of HA. The effect of a significant gene-gene interaction between the SLC6A4 and BDNF genes on HA could explain part of the genetic basis underlying anxiety-related traits. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Wiley-Blackwell | ca_CA |
dc.relation.isPartOf | Acta Psychiatrica Scandinavica, Volume 125, Number 3, 1 March 2012 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | harm avoidance | ca_CA |
dc.subject | 5-HTT gene | ca_CA |
dc.subject | BDNF gene | ca_CA |
dc.subject | GABRA6 gene | ca_CA |
dc.title | The role of genetic variability in the GABRA6, 5-HTT and BDNF genes in anxiety-related traits | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1111/j.1600-0447.2011.01764.x | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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