Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reaction
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Scholar |
Otros documentos de la autoría: Escrig, Miguel A.; Pardo Andrés, Marta; González Aragón, Carlos Manuel; Correa, Merce
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
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http://dx.doi.org/10.1016/j.pbb.2011.10.002 |
Metadatos
Título
Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reactionFecha de publicación
2012Editor
ElsevierISSN
0091-3057Cita bibliográfica
Pharmacology Biochemistry and Behavior (Jan. 2012) vol. 100, no. 3, p. 404-412Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0091305711003248Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called “flushing”. The aversive characteristics of flushing observed in some populations with an isoform ... [+]
Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called “flushing”. The aversive characteristics of flushing observed in some populations with an isoform of aldehyde dehydrogenase (ALDH2) less active, are the basis for treating alcoholics with disulfiram, an ALDH inhibitor. Although ethanol and centrally formed acetaldehyde have anxiolytic effects, peripheral accumulation of acetaldehyde may be aversive in part because it is anxiogenic. [-]
Derechos de acceso
© 2012 Elsevier Inc. All rights reserved
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