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dc.contributor.authorSalom Roig, Xavier J.
dc.contributor.authorMartínez, Jean
dc.contributor.authorBurguete, M. Isabel
dc.contributor.authorGalindo, Francisco
dc.contributor.authorLuis, Santiago V.
dc.contributor.authorMiranda, Miguel A.
dc.contributor.authorMorant Miñana, M. C.
dc.contributor.authorPérez Prieto, Julia
dc.date.accessioned2012-08-07T09:56:07Z
dc.date.available2012-08-07T09:56:07Z
dc.date.issued2009
dc.identifierhttp://dx.doi.org/10.1016/j.tetlet.2009.06.047
dc.identifier.citationTetrahedron Letters, 50, 34, p. 4859-4862
dc.identifier.issn404039
dc.identifier.urihttp://hdl.handle.net/10234/43762
dc.description.abstractThe behavior of 6 pseudopeptidic models, synthesized by connecting different protected amino acids (Trp, Tyr, Phe, and Lys) with various diamino spacers, as quenchers of the triplet excited state of tiaprofenic acid (and its methyl ester), has been investigated. A series of quenching constants have been determined, which depend on the nature of the quencher and on the stereochemistry of the excited drug. A significant degree of stereodifferentiation has been found for the peptidomimetic synthesized with Phe and Tyr linked by a piperazine bridge. The obtained results support the utility of laser flash photolysis (LFP) as a tool to investigate the interactions between photoexcited drugs and simple models of binding sites in proteins. © 2009 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.publisherElsevier
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectLaser flash photolysis
dc.subjectPhotochemistry
dc.subjectQuenching
dc.subjectTriplet excited state
dc.titleChiral synthetic pseudopeptidic derivatives as triplet excited state quenchers
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doihttp://dx.doi.org/10.1016/j.tetlet.2009.06.047
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess


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