Listar MED_Articles por autoría "63fd5775-42da-4955-b063-3002dfb3adb7"
Mostrando ítems 1-4 de 4
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JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study
MILARA, JAVIER; Ballester, Beatriz; Morell, Anselm; Ortiz, José L.; Escrivá, Juan; Fernández, Estrella; Pérez-Vizcaino, Francisco; Cogolludo, Ángel; Pastor, Enrique; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio BMJ (2018)Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators approved for PH have failed in improving IPF ... -
MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps
MILARA, JAVIER; Morell, Anselm; Ballester, Beatriz; Armengot, Miguel; Morcillo, Esteban; Cortijo, Julio Elsevier (2016)Background Current evidence suggests that membrane-tethered mucins could mediate corticosteroid efficacy, interacting with glucocorticoid receptor (GR) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). ... -
Mucin 1 deficiency mediates corticosteroid insensitivity in asthma
MILARA, JAVIER; Morell, Anselm; de Diego, Alfredo; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio Wiley (2019-01)BACKGROUND: The loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin ... -
The JAK2 pathway is activated in idiopathic pulmonary fibrosis
MILARA, JAVIER; Hernandez, Gracia; Ballester, Beatriz; Morell, Anselm; Roger, Inés; Montero, P.; Escrivá, Juan; Lloris, José M.; Molina Molina, Maria; Morcillo, Esteban; Cortijo, Julio BioMed Central (2018)Background: Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated ...