Why should we keep the cerebellum in mind when thinking about addiction?
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Otros documentos de la autoría: MIQUEL, MARTA; Toledo, Rebeca; García, Luis I.; Coria Ávila, Genaro A.; Manzo, Jorge
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Why should we keep the cerebellum in mind when thinking about addiction?Fecha de publicación
2009Editor
Bentham Science PublishersISSN
1874-4737Cita bibliográfica
MIQUEL, Marta, et al. Why should we keep the cerebellum in mind when thinking about addiction?. Current drug abuse reviews, 2009, vol. 2, no 1, p. 26-40.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://pubmed.ncbi.nlm.nih.gov/19630735/Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
Increasing evidence has involved the cerebellum in functions beyond the sphere of
motor control. In the present article, we review evidence that involves the cerebellum in
addictive behaviour. We aimed on molecular ... [+]
Increasing evidence has involved the cerebellum in functions beyond the sphere of
motor control. In the present article, we review evidence that involves the cerebellum in
addictive behaviour. We aimed on molecular and cellular targets in the cerebellum
where addictive drugs can act and induce mechanisms of neuroplasticity that may
contribute to the development of an addictive pattern of behaviour. Also, we analyzed
the behavioural consequences of repetitive drug administration that result from activitydependent changes in the efficacy of cerebellar synapses. Revised research involves the cerebellum in drug-induced long-term memory, druginduced
sensitization and the perseverative behavioural phenotype. Results agree to
relevant participation of the cerebellum in the functional systems underlying drug
addiction. The molecular and cellular actions of addictive drugs in the cerebellum
involve long-term adaptative changes in receptors, neurotransmitters and intracellular
signalling transduction pathways that may lead to the re-organization of cerebellar
microzones and in turn to functional networks where the cerebellum is an important
nodal structure. We propose that drug induced activity-dependent synaptic changes in
the cerebellum are crucial to the transition from a pattern of recreational drug taking to
the compulsive behavioural phenotype. Functional and structural modifications
produced by drugs in the cerebellum may enhance the susceptibility of fronto-cerebellar
circuitry to be changed by repeated drug exposure. As a part of this functional
reorganization, drug-induced cerebellar hyper-responsiveness appears to be central to
reducing the influence of executive control of the prefrontal cortex on behaviour and
aiding the transition to an automatic mode of control [-]
Publicado en
Current drug abuse reviews, 2009, v. 2, n. 1Derechos de acceso
© Bentham Science Publishers
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info:eu-repo/semantics/openAccess
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