Study of biological properties of gold nanoparticles: Low toxicity, no proliferative activity, no ability to induce cell gene expression and no antiviral activity
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Otros documentos de la autoría: Salesa Landete, Beatriz; Ferrús-Manzano, Patricia; Tuñón Molina, Alberto; Cano-Vicent, Alba; Assis, Marcelo de; Andres, Juan; Serrano-Aroca, Ángel
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
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Título
Study of biological properties of gold nanoparticles: Low toxicity, no proliferative activity, no ability to induce cell gene expression and no antiviral activityAutoría
Fecha de publicación
2023-07-26Editor
ElsevierCita bibliográfica
SALESA, Beatriz, et al. Study of biological properties of gold nanoparticles: Low toxicity, no proliferative activity, no ability to induce cell gene expression and no antiviral activity. Chemico-Biological Interactions, 2023, vol. 382, p. 110646.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
Gold nanoparticles (AuNPs) are a fundamental building block of many applications across nanotechnology as they have excellent biosafety which make them promising for a broad range of biomedical applications. Here we ... [+]
Gold nanoparticles (AuNPs) are a fundamental building block of many applications across nanotechnology as they have excellent biosafety which make them promising for a broad range of biomedical applications. Here we explore their in vivo toxicity, cytotoxicity and proliferative capacity in human keratinocyte HaCaT cells, their ability to induce gene expression and their antiviral properties against a surrogate of SARS-CoV-2. These nanoparticles were characterized by transmission electron microscopy, dynamic light scattering and zeta potential. The results showed that these AuNPs with sizes ranging from 10 to 60 nm are non-toxic in vivo at any concentration up to 800 μg/mL. However, AuNP cytotoxicity in human HaCaT cells is time-dependent, so that concentrations of up to 300 μg/mL did not show any in vitro toxic effect at 3, 12 and 24 h, although higher concentrations were found to have some significant toxic activity, especially at 24 h. No significant proliferative activity was observed when using low AuNP concentrations (10, 20 and 40 μg/mL), while the AuNP antiviral tests indicated low or insignificant antiviral activity. Surprisingly, none of the 13 analyzed genes had their expressions modified after 24 h's exposure to AuNPs. Therefore, the results show that AuNPs are highly stable inactive materials and thus very promising for biomedical and clinical applications demanding this type of materials. [-]
Entidad financiadora
Fundación Universidad Católica de Valencia San Vicente Mártir | Universitat Jaume I | Generalitat Valenciana | Ministerio de Ciencia, Innovación y Universidades (Spain) | European Union Next Generation EU
Código del proyecto o subvención
2020-231-006UCV | PID2020-119333RB-I00/AEI/10.13039/501100011033 | UJI-B2019-30 | AICO2020 | PGC2018- 094417-B-I00 | MGS/2021/21 (UP2021-021)
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© 2023 Elsevier B.V. All rights reserved.
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