Neuroinflammation as a possible link between attention-deficit/ hyperactivity disorder (ADHD) and pain
comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Neuroinflammation as a possible link between attention-deficit/ hyperactivity disorder (ADHD) and painFecha de publicación
2021Editor
ELSEVIERISSN
0306-9877Cita bibliográfica
KEREKES, Nóra; SANCHÉZ-PÉREZ, Ana Maria; LANDRY, Marc. Neuroinflammation as a possible link between attention-deficit/hyperactivity disorder (ADHD) and pain. Medical hypotheses, 2021, 157: 110717.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Attention-deficit/hyperactivity disorder (ADHD) and pathological pain are two complex syndromes of multifactorial origin. Despite their prevalence and broad impacts, these conditions are seldom recognized and managed ... [+]
Attention-deficit/hyperactivity disorder (ADHD) and pathological pain are two complex syndromes of multifactorial origin. Despite their prevalence and broad impacts, these conditions are seldom recognized and managed simultaneously. The co-existence of neuropsychiatric conditions (such as ADHD) and altered pain perception and chronic pain has been noted in children, and the comorbidity of ADHD and chronic pain is well documented in adults. Pathophysiological studies have suggested dysfunction of the dopaminergic system as a common neurochemical basis for comorbid ADHD and pain. Considerable evidence supports the role of neuroinflammation in the pathophysiology of both.
We suggest that central neuroinflammation underlies altered pain perception and pain sensitization in persons with ADHD.
Based on our hypothesis, targeting neuroinflammation may serve as a potential new therapeutic intervention to treat ADHD and comorbid pain in children and adolescents and a preventive strategy for the development of chronic pain in adults with ADHD. [-]
Publicado en
Medical Hypotheses Volume 157, December 2021Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- INAM_Articles [514]
- MED_Articles [645]