The relevant role of ion mobility separation in LC-HRMS based screening strategies for contaminants of emerging concern in the aquatic environment
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Otros documentos de la autoría: Celma, Alberto; Ahrens, Lutz; Gago-Ferrero, Pablo; Hernandez, Felix; Lopez, Francisco; Lundqvist, Johan; Pitarch, Elena; Sancho, Juan V; Wiberg, Karin; Bijlsma, Lubertus
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Título
The relevant role of ion mobility separation in LC-HRMS based screening strategies for contaminants of emerging concern in the aquatic environmentAutoría
Fecha de publicación
2021-05-05Editor
ElsevierCita bibliográfica
CELMA, Alberto, et al. The relevant role of ion mobility separation in LC-HRMS based screening strategies for contaminants of emerging concern in the aquatic environment. Chemosphere, 2021, 280, 130799.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Ion mobility separation (IMS) coupled to high resolution mass spectrometry (IMS-HRMS) is a promising technique for (non-)target/suspect analysis of micropollutants in complex matrices. IMS separates ionized compounds ... [+]
Ion mobility separation (IMS) coupled to high resolution mass spectrometry (IMS-HRMS) is a promising technique for (non-)target/suspect analysis of micropollutants in complex matrices. IMS separates ionized compounds based on their charge, shape and size facilitating the removal of co-eluting isomeric/isobaric species. Additionally, IMS data can be translated into collision cross-section (CCS) values, which can be used to increase the identification reliability. However, IMS-HRMS for the screening of contaminants of emerging concern (CECs) have been scarcely explored. In this study, the role of IMS-HRMS for the identification of CECs in complex matrices is highlighted, with emphasis on when and with which purpose is of use. The utilization of IMS can result in much cleaner mass spectra, which considerably facilitates data interpretation and the obtaining of reliable identifications. Furthermore, the robustness of IMS measurements across matrices permits the use of CCS as an additional relevant parameter during the identification step even when reference standards are not available. Moreover, an effect on the number of true and false identifications could be demonstrated by including IMS restrictions within the identification workflow. Data shown in this work is of special interest for environmental researchers dealing with the detection of CECs with state-of-the-art IMS-HRMS instruments. [-]
Publicado en
Chemosphere Volume 280, October 2021Entidad financiadora
Swedish Research Council (FORMAS) | Spanish Ministry of Science, Innovation and Universities | Generalitat Valenciana | Universitat Jaume I | Spanish Ministry of Economy and Competiveness
Código del proyecto o subvención
2018–02256 | RTI 2018-097417-B-100 | 2019/040 | UJI-B2018-55 | UJI-B2020-19 | BES-2016-076914
Título del proyecto o subvención
“Effect-directed analysis as a tool towards a non-toxic environment - identification of mixture effects and toxicity drivers in water (DANTE)” project | Research Group of Excellence Prometeo
Derechos de acceso
info:eu-repo/semantics/openAccess
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