LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients
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Altres documents de l'autoria: Garlito Molina, Borja; Ibáñez, Maria; Portoles, Tania; Serrano, Roque; Amlund, Heidi; Lundebye, Anne-Katrine; Sanden, Monica; Berntssen, Marc H. G.; Hernandez, Felix
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https://doi.org/10.1007/s00216-019-02104-6 |
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LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredientsAutoria
Data de publicació
2019Editor
SpringerISSN
1618-2642; 1618-2650Cita bibliogràfica
Garlito, B., Ibáñez, M., Portolés, T. et al. LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients. Anal Bioanal Chem 411, 7281–7291 (2019). https://doi.org/10.1007/s00216-019-02104-6Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://link.springer.com/article/10.1007/s00216-019-02104-6Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
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The composition of Atlantic salmon feed has changed considerably over the last two decades from being marine-based (fishmeal and fish oil) to mainly containing plant ingredients. Consequently, concern related to ... [+]
The composition of Atlantic salmon feed has changed considerably over the last two decades from being marine-based (fishmeal and fish oil) to mainly containing plant ingredients. Consequently, concern related to traditional persistent contaminants typically associated with fish-based feed has been replaced by other potential contaminants not previously associated with salmon farming. This is the case for many pesticides, which are used worldwide to increase food production, and may be present in plant ingredients. Earlier studies have identified two organophosphorus pesticides, chlorpyrifos-methyl and pirimiphos-methyl, in plant ingredients used for aquafeed production. In the present study, we developed a reliable and sensitive analytical method, based on liquid chromatography coupled to tandem mass spectrometry, for the determination of these pesticides and their main metabolites in warm water (zebrafish) and cold water (Atlantic salmon) species, where possible differences in metabolites could be expected. The method was tested in whole zebrafish and in different salmon tissues, such as muscle, bile, kidney, fat, and liver. The final objective of this work was to assess kinetics of chlorpyrifos-methyl and pirimiphos-methyl and their main metabolites in fish tissue, in order to fill the knowledge gaps on these metabolites in fish tissues when fed over prolonged time. [-]
Publicat a
Analytical and bioanalytical chemistry, 2019, vol. 411, no 27Proyecto de investigación
Norwegian Research Council (NFR) project “AQUASAFE” (254807)Drets d'accés
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