Comparative degradation of two highly consumed antihypertensives in water by sonochemical process. Determination of the reaction zone, primary degradation products and theoretical calculations on the oxidative process
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Otros documentos de la autoría: Serna-Galvis, Efraim A.; Isaza-Pineda, Laura; Moncayo-Lasso, Alejandro; Hernandez, Felix; Ibáñez, Maria; Torres-Palma, Ricardo A.
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https://doi.org/10.1016/j.ultsonch.2019.104635 |
Metadatos
Título
Comparative degradation of two highly consumed antihypertensives in water by sonochemical process. Determination of the reaction zone, primary degradation products and theoretical calculations on the oxidative processAutoría
Fecha de publicación
2019Editor
ElsevierISSN
1350-4177; 1873-2828Cita bibliográfica
SERNA-GALVIS, Efraim A., et al. Comparative degradation of two highly consumed antihypertensives in water by sonochemical process. Determination of the reaction zone, primary degradation products and theoretical calculations on the oxidative process. Ultrasonics Sonochemistry, 2019, p. 104635Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S1350417719303979Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
This work compares the sonochemical degradation of losartan and valsartan (antihypertensives) in water. Initially, the suitable operational conditions of ultrasonic power density and frequency were established. Under ... [+]
This work compares the sonochemical degradation of losartan and valsartan (antihypertensives) in water. Initially, the suitable operational conditions of ultrasonic power density and frequency were established. Under such conditions, losartan was eliminated in a higher percentage than valsartan, which was associated to differences in their hydrophobicities. Additionally, degradations in presence of isopropanol and ferrous ions confirmed that losartan was closer to cavitation bubble than valsartan. The structures of primary products indicated that sonogenerated hydroxyl radical attacked biphenyl tetrazole moiety (common nucleus of both pharmaceuticals). Then, theoretical calculations were applied to the products to estimate the toxicity, degree of oxidation and probable routes of aerobic biodegradation suggesting a beneficial action of sonodegradation. Finally, the sonochemical degradation of the antihypertensives was carried out in two simulated complex matrices (i.e., seawater and hospital wastewater) and an actual wastewater. Interestingly, the losartan and valsartan eliminations in such waters were similar to the observed in distilled water. This fact indicates the high potentiality of ultrasound to degrade losartan or valsartan in waters containing other substances, even at higher concentrations than these pollutants. [-]
Publicado en
Ultrasonics Sonochemistry, 2019, p. 104635Proyecto de investigación
heauthorsthankUniversidaddeAntioquiaUdeAforthesupportprovidedtotheirresearchgroupthrough“ProgramadeSostenibilidad”and the financing from COLCIENCIAS through the projects No.111577757323 (Convocatoria 777 de 2017) and No. 123371552034(Convocatoria 715 de 2015). The authors from UJI acknowledge thefinancial support from Generalitat Valenciana (Research Group ofExcellence, PrometeoII/2014/023). The authors from UniversidadAntonio Nariño acknowledge the funding from UAN (Colombia)throughtheprojectNo.2018208.E.A.Serna-GalvisthanksthedoctoralscholarshipfromCOLCIENCIAS(Convocatoria647de2014)Derechos de acceso
© 2019 Elsevier B.V. All rights reserved.
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