Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy Controls
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Otros documentos de la autoría: Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Miró-Padilla, Anna; Bueichekú, Elisenda; Broseta Torres, Ricardo; Avila, Cesar; Sanchis-Segura, Carla; Forn, Cristina
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comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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INVESTIGACIONMetadatos
Título
Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy ControlsAutoría
Fecha de publicación
2019Editor
HindawiISSN
2090-2654; 2090-2662Cita bibliográfica
AGUIRRE, Naiara, et al. Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy Controls. Multiple sclerosis international, 2019, vol. 2019.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.hindawi.com/journals/msi/2019/2657902/Versión
info:eu-repo/semantics/publishedVersionResumen
Background/Objective. To explore the efectiveness of a specifc working memory (WM) training program in MS patients and
healthy controls (HC). Method. 29 MS patients and 29 matched HC were enrolled in the study. MS ... [+]
Background/Objective. To explore the efectiveness of a specifc working memory (WM) training program in MS patients and
healthy controls (HC). Method. 29 MS patients and 29 matched HC were enrolled in the study. MS and HC were randomly split into
two groups: nontraining groups (15HC/14 MS) and training groups (14 HC/15 MS). Training groups underwent adaptive n-back
training (60 min/day; 4 days). Functional magnetic resonance imaging (fMRI) was used to monitor brain activity during n-back
performance (conditions: 0-back, 2-back, and 3-back) at 3 time points: (1) baseline, (2) post-training (+7days), and (3) followup (+35days). Results. In post-training and follow-up fMRI sessions, trained groups (HC and MS patients) exhibited signifcant
reaction time (RT) reductions and increases in Correct Responses (CRs) during 2-back and 3-back performance.Tis improvement
of task performance was accompanied by a decrease in brain activation in the WM frontoparietal network. Te two efects were
signifcantly correlated. Conclusions. Afer WM training, both cognitively preserved MS patients and HC participants showed task
performance improvement made possible by neuroplastic processes that enhanced neural efciency. [-]
Publicado en
Multiple Sclerosis International Volume 2019, Article ID 2657902Proyecto de investigación
PSI2015-67285-R ; UJI B2017-05 ; FPU16/01525Derechos de acceso
info:eu-repo/semantics/openAccess
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