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dc.contributor.authorAlbert Gasco, Hector
dc.contributor.authorSánchez-Sarasúa, Sandra
dc.contributor.authorMa, Sherie
dc.contributor.authorGarcía Díaz, Cristina
dc.contributor.authorGundlach, Andrew Lawrence
dc.contributor.authorSánchez-Pérez, Ana María
dc.contributor.authorOlucha-Bordonau, Francisco E
dc.date.accessioned2019-04-30T07:11:43Z
dc.date.available2019-04-30T07:11:43Z
dc.date.issued2019-01
dc.identifier.citationALBERT-GASCÓ, Héctor, et al. Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons. Brain Structure and Function, 2019, vol. 224, no 1, p. 453-469ca_CA
dc.identifier.issn1863-2653
dc.identifier.issn1863-2661
dc.identifier.urihttp://hdl.handle.net/10234/182382
dc.descriptionThis is a pre-print of an article published in Brain Structure and Function. The final authenticated version is available online at: https://doi.org/10.1007/s00429-018-1763-5
dc.description.abstractIn mammals, the extended amygdala is a neural hub for social and emotional information processing. In the rat, the extended amygdala receives inhibitory GABAergic projections from the nucleus incertus (NI) in the pontine tegmentum. NI neurons produce the neuropeptide relaxin-3, which acts via the Gi/o-protein-coupled receptor, RXFP3. A putative role for RXFP3 signalling in regulating social interaction was investigated by assessing the effect of intracerebroventricular infusion of the RXFP3 agonist, RXFP3-A2, on performance in the 3-chamber social interaction paradigm. Central RXFP3-A2, but not vehicle, infusion, disrupted the capacity to discriminate between a familiar and novel conspecific subject, but did not alter differentiation between a conspecific and an inanimate object. Subsequent studies revealed that agonist-infused rats displayed increased phosphoERK(pERK)-immunoreactivity in specific amygdaloid nuclei at 20 min post-infusion, with levels similar to control again after 90 min. In parallel, we used immunoblotting to profile ERK phosphorylation dynamics in whole amygdala after RXFP3-A2 treatment; and multiplex histochemical labelling techniques to reveal that after RXFP3-A2 infusion and social interaction, pERK-immunopositive neurons in amygdala expressed vesicular GABA-transporter mRNA and displayed differential profiles of RXFP3 and oxytocin receptor mRNA. Overall, these findings demonstrate that central relaxin-3/RXFP3 signalling can modulate social recognition in rats via effects within the amygdala and likely interactions with GABA and oxytocin signalling.ca_CA
dc.format.extent17 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherSpringerca_CA
dc.relation.isPartOfBrain Structure and Function, 2019, vol. 224, no 1ca_CA
dc.rights© Springer-Verlag GmbH Germany, part of Springer Natureca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectarousalca_CA
dc.subjectemotionca_CA
dc.subjectnucleus incertusca_CA
dc.subjectoxytocin receptorca_CA
dc.titleCentral relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neuronsca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1007/s00429-018-1763-5
dc.relation.projectIDUniversitat Jaume I: UJI-B2016-40; Program of Mobilities of the Spanish Ministerio de Educación y Cultura: PRX17/00646; Universitat Jaume I FPI-UJI Predoctoral Research Scholarship: PREDOC/2014/35; Plan Propi Universitat Jaume I: P1.1A2014-06; NHMRC (Australia): 1067522; Research Travel Grant: E-2016-43; Dorothy Levien Foundationca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://link.springer.com/article/10.1007/s00429-018-1763-5ca_CA
dc.type.versioninfo:eu-repo/semantics/submittedVersionca_CA


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