Mostrar el registro sencillo del ítem

dc.contributor.authorOlucha-Bordonau, Francisco E
dc.contributor.authorAlbert Gasco, Hector
dc.contributor.authorRos Bernal, Francisco
dc.contributor.authorRytova, Valeria
dc.contributor.authorOng-Pålsson, Emma ­K. ­E.­
dc.contributor.authorMa, Shuai
dc.contributor.authorSánchez-Pérez, Ana María
dc.contributor.authorGundlach, Andrew Lawrence
dc.date.accessioned2018-11-15T08:48:02Z
dc.date.available2018-11-15T08:48:02Z
dc.date.issued2018
dc.identifier.citationOLUCHA‐BORDONAU, Francisco E., et al. Modulation of forebrain function by nucleus incertus and relaxin‐3/RXFP 3 signaling. CNS neuroscience & therapeutics, 2018, vol. 24, no 8, p. 694-702ca_CA
dc.identifier.issn1755-5930
dc.identifier.issn1755-5949
dc.identifier.urihttp://hdl.handle.net/10234/177484
dc.descriptionThis is the pre-peer reviewed version of the following article: Modulation of forebrain function by nucleus incertus and relaxin‐3/RXFP3 signaling, CNS neuroscience & therapeutics, 2018, vol. 24, no 8, p. 694-702, which has been published in final form at https://doi.org/10.1111/cns.12862. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.description.abstractThe nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several forebrain functions. A substantial population of GABAergic NI neurons expresses the neuropeptide, relaxin‐3, which acts via the Gi/o‐protein‐coupled receptor, RXFP3, present throughout the forebrain target regions. Broad and specific manipulations of these systems by activation or inhibition of the NI or modulating RXFP3 signaling have revealed key insights into the likely influence of the NI/relaxin‐3/RXFP3 system on modalities including arousal, feeding, stress responses, anxiety and addiction, and attention and memory. This range of actions corresponds to a likely impact of NI/(relaxin‐3) projections on multiple integrated circuits, but makes it difficult to draw conclusions about a generalized function for this network. This review will focus on the key physiological process of oscillatory theta rhythm and the neural circuits that promote it during behavioral activation, highlighting the ability of NI and relaxin‐3/RXFP3 signaling systems to modulate these circuits. A better understanding of these mechanisms may provide a way to therapeutically adjust malfunction of forebrain activity present in several pathological conditions.ca_CA
dc.format.extent9 p.ca_CA
dc.language.isoengca_CA
dc.publisherWileyca_CA
dc.relation.isPartOfCNS neuroscience & therapeutics, 2018, vol. 24, no 8ca_CA
dc.rightsCopyright © John Wiley & Sons, Inc.ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectarousalca_CA
dc.subjectbrainstemca_CA
dc.subjectfeedingca_CA
dc.subjectGABAca_CA
dc.subjecthippocampusca_CA
dc.subjectseptumca_CA
dc.subjectsocial interactionca_CA
dc.subjecttheta rhythmca_CA
dc.titleModulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signalingca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1111/cns.12862
dc.relation.projectIDUniversitat Jaume I / UJI-B2016-40; Spanish Ministerio de Educacion y Cultura Mobility Program / PRX17/00646; Universitat Jaume I FPI-UJI Predoctoral Research Scholarship / PREDOC/2014/35 E-2016-43; NHMRC (Australia) / 1067522; Dorothy Levien Foundationca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://onlinelibrary.wiley.com/doi/full/10.1111/cns.12862ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem