Effects of lactisole on pancreatic islet B-cells electrophysiology

Abstract

Sucralose mimics the effects of glucose upon several variables of pancreatic islet B-cell metabolism and function, including bioelectrical activity. The present study aimed at investigating whether lactisole, which was recently found to act as an antagonist of the sweet taste receptor TIR3 in pancreatic islet B-cells, also opposes the effects of glucose and/or sucralose upon B-cell electrophysiology. A dual effect of lactisole, both inhibitory and stimulatory, was observed upon the electrical activity of mouse pancreatic islet B-cells. The present findings thus document that agents supposed to act specifically on the TIR3 sweet receptor may either mimic or oppose the effect of glucose upon islet B-cell electrical activity.