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Prediction of suboptimal cytoreductive surgery in patients with advanced ovarian cancer based on preoperative and intraoperative determination of the peritoneal carcinomatosis index
dc.contributor.author | Llueca, Antoni | |
dc.contributor.author | Serra Rubert, Anna | |
dc.contributor.author | Rivadulla, Isabel | |
dc.contributor.author | Gomez, Luis | |
dc.contributor.author | Escrig-Sos, Javier | |
dc.contributor.author | MUAPOS (Multidisciplinary Unit of Abdominal Pelvic Oncology Surgery) | |
dc.date.accessioned | 2018-05-17T18:32:32Z | |
dc.date.available | 2018-05-17T18:32:32Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | LLUECA, Antoni, et al. Prediction of suboptimal cytoreductive surgery in patients with advanced ovarian cancer based on preoperative and intraoperative determination of the peritoneal carcinomatosis index. World journal of surgical oncology, 2018, vol. 16, núm. 1, p.37 | ca_CA |
dc.identifier.issn | 1477-7819 | |
dc.identifier.uri | http://hdl.handle.net/10234/174734 | |
dc.description.abstract | Background The peritoneal carcinomatosis index (PCI) can be used to quantify the tumor burden in patients with advanced ovarian cancer. The aim of the present study was to establish a predictive model for suboptimal cytoreductive surgery (SCS) (residual tumor of > 1 cm) using preoperative and intraoperative determination of the PCI. Methods In total, 110 consecutive patients treated for advanced ovarian cancer during a 4-year period in our institution were assessed. Eighty of these patients were eligible for primary debulking surgery and thus included in the present study. All data were prospectively collected and retrospectively evaluated. We determined the PCI both preoperatively and intraoperatively and assessed postoperative complications. Results A PCI of > 20 was the best cut-off with which to predict a risk of SCS among all three diagnostic techniques assessed in this study (computed tomography, laparoscopy, and laparotomy). Intraoperative PCI determination was associated with the lowest risk of false negatives for SCS when detecting a PCI of < 20. The combination of preoperative computed tomography and laparoscopy, when both techniques predicted SCS, was associated with the lowest risk of false positives for SCS when detecting a PCI of > 20. Conclusion The combination of computed tomography and laparoscopy to obtain the PCI can help to determine which patients with advanced ovarian cancer are suitable for primary debulking surgery and which should undergo neoadjuvant chemotherapy. | ca_CA |
dc.format.extent | 7 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | BioMed Central | ca_CA |
dc.relation.isPartOf | World journal of surgical oncology, 2018, vol. 16, núm. 1, p.37 | ca_CA |
dc.rights | © The Author(s). 2018 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | advanced ovarian cancer | ca_CA |
dc.subject | cytoreductive surgery | ca_CA |
dc.subject | peritoneal carcinomatosis index | ca_CA |
dc.title | Prediction of suboptimal cytoreductive surgery in patients with advanced ovarian cancer based on preoperative and intraoperative determination of the peritoneal carcinomatosis index | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1186/s12957-018-1339-0 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1339-0 | ca_CA |
dc.contributor.funder | This work received financial support from de Medtronic University Chair for Training and Surgical Research (University Jaume I (UJI), Castellon, Spain). | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.