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dc.contributor.authorAmorós Salvador, Rubén
dc.contributor.authorMurcia, Mario
dc.contributor.authorBallester, Ferran
dc.contributor.authorBroberg, Karin
dc.contributor.authorIñiguez, Carmen
dc.contributor.authorRebagliato, Marisa
dc.contributor.authorSkröder, Helena
dc.contributor.authorGonzález, Llúcia
dc.contributor.authorLópez Espinosa, María José
dc.contributor.authorLlop, Sabrina
dc.identifier.citationAMORÓS, Rubén, et al. Selenium status during pregnancy: influential factors and effects on neuropsychological development among Spanish infants. Science of The Total Environment, 2018, vol. 610-611, p.741-749ca_CA
dc.description.abstractSelenium (Se) has been positively associated with neurodevelopment in early life. However, its margin of safety is rather narrow, and few prospective studies have evaluated its potential neurotoxic effects at intermediate levels. We aimed to explore the association between maternal Se concentrations and child neuropsychological development, including the genetic effect modification of the Se metabolizing gene INMT. Study subjects were 650 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003–2005). Infant neuropsychological development was assessed around 12 months of age by the Bayley Scales of Infant Development. Sociodemographic and dietary characteristics were collected by questionnaire at the first and third trimester of gestation. Se was measured in serum samples at the first trimester. The mean serum Se concentration was 79.7 (standard deviation = 7.9) μg/L. In multivariate analysis, nonsignificant inverse linear associations were found between Se concentrations and standardized mental and psychomotor development scores (β (95% CI) = − 0.13 (− 0.29, 0.03) and β (95% CI) = − 0.08 (− 0.24, 0.07), respectively). Generalized additive models indicated inverted U-shaped relationships between Se concentrations and both scales. Using segmented regression, the turning point for the associations was estimated at 86 μg/L for both scales. The association between Se and neuropsychological development was inverted U-shaped for children with the AG + AA genotype for rs6970396 INMT but a descending curve was suggested for the GG genotype. Further studies would be necessary in order to disentangle the complex equilibrium between the toxicity and benefits of Se exposure during the prenatal period.ca_CA
dc.format.extent9 p.ca_CA
dc.relation.isPartOfScience of The Total Environment, 2018, vol. 610-611, p.741-749ca_CA
dc.rights© 2017 Elsevier B.V. All rights reservedca_CA
dc.subjecttrace elementca_CA
dc.titleSelenium status during pregnancy: Influential factors and effects on neuropsychological development among Spanish infantsca_CA
dc.relation.projectIDThis study was supported by the European Union [grant numbers FP7-ENV-2011, cod 282957, HEALTH.2010.2.4.5-1]; Instituto de Salud Carlos III [grant numbers Red INMA G03/176, CB06/02/0041, FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI14/0891, PI14/1687, PI16/1288 and Programa Miguel Servet-FEDER: grant numbers CP11/0178, CP15/0025 and CPII16/0051]; Fundació per al Foment de la Investigació Sanitària i Biomèdica de la Comunitat Valenciana (FISABIO) [grant numbers UGP-15-230, UGP-15-244, UGP-15-249]; the Conselleria de Sanitat, Generalitat Valenciana; and the Karolinska Institutet.ca_CA

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