Brain insulin signaling in Alzheimer's disease
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Título
Brain insulin signaling in Alzheimer's diseaseAutoría
Tutor/Supervisor; Universidad.Departamento
Sánchez Pérez, Ana María; Universitat Jaume I. Unitat Predepartamental de MedicinaFecha de publicación
2017Editor
Universitat Jaume IResumen
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most
common cause of dementia affecting elderly people. Its pathological hallmarks are the
presence of extracellular aggregates of amyloid-β ... [+]
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most
common cause of dementia affecting elderly people. Its pathological hallmarks are the
presence of extracellular aggregates of amyloid-β peptide (Aβ), also known as senile
plaques, and intracellular clusters of hyperphosphorylated tau protein, commonly
called neurofibrillary tangles (NFTs). Classically, the brain was considered to be
insulin-insensitive, but evidence has proved the contrary and now it is widely accepted
that insulin and IGF-1 have neuromodulatory actions. Insulin signaling is involved in
various neuronal functions such as synapse transmission, cognition, learning and
memory. Insulin resistance, together with AβOs neurotoxicity, neuronal metabolic
stress and neuroinflammation, has been shown to play a role in AD pathogenesis. In
this review we will describe the connection between neuronal insulin signaling and the
pathogenesis and progression of AD, as well as the new promising therapeutic
approaches focused on the insulin signaling pathway that are being researched, such
as intranasal insulin or insulin sensitizing agents. [-]
Palabras clave / Materias
Descripción
Treball Final de Grau en Medicina. Codi: MD1158. Curs acadèmic: 2016-2017
Tipo de documento
info:eu-repo/semantics/bachelorThesisDerechos de acceso
Licencia CC-BY-NC-SA
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- Grau en Medicina [494]
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