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The interaction of amino acids with macrocyclic pH probes of pseudopeptidic nature
dc.contributor.author | Izquierdo Arcusa, María Ángeles | |
dc.contributor.author | Wadhavane, Prashant Dinkar | |
dc.contributor.author | Vigara, Laura | |
dc.contributor.author | Burguete, M. Isabel | |
dc.contributor.author | Galindo, Francisco | |
dc.contributor.author | Luis, Santiago V. | |
dc.date.accessioned | 2017-11-28T12:29:43Z | |
dc.date.available | 2017-11-28T12:29:43Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Photochem. Photobiol. Sci., 2017, 16, 1320 | ca_CA |
dc.identifier.issn | 1474-905X | |
dc.identifier.issn | 1474-9092 | |
dc.identifier.uri | http://hdl.handle.net/10234/170570 | |
dc.description.abstract | The fluorescence quenching, by a series of amino acids, of pseudopeptidic compounds acting as probes for cellular acidity has been investigated. It has been found that amino acids containing electron-rich aromatic side chains like Trp or Tyr, as well as Met quench the emission of the probes mainly via a collisional mechanism, with Stern–Volmer constants in the 7–43 M−1 range, while other amino acids such as His, Val or Phe did not cause deactivation of the fluorescence. Only a minor contribution of a static quenching due to the formation of ground-state complexes has been found for Trp and Tyr, with association constants in the 9–24 M−1 range. For these ground-state complexes, a comparison between the macrocyclic probes and an open chain analogue reveals the existence of a moderate macrocyclic effect due to the preorganization of the probes in the more rigid structure. | ca_CA |
dc.format.extent | 7 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Royal Society of Chemistry | ca_CA |
dc.relation.isPartOf | Photochem. Photobiol. Sci., 2017, 16, 1320–1326 | ca_CA |
dc.rights | This journal is © The Royal Society of Chemistry and Owner Societies 2017 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.title | The interaction of amino acids with macrocyclic pH probes of pseudopeptidic nature | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://doi.org/10.1039/c7pp00167c | |
dc.relation.projectID | CTQ2015-68429-R ; P1·1B-2012-41 | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://pubs.rsc.org/en/content/articlelanding/2017/pp/c7pp00167c#!divAbstract | ca_CA |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
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