Distributions and determinants of urinary biomarkers of organophosphate pesticide exposure in a prospective Spanish birth cohort study
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Otros documentos de la autoría: Llop, Sabrina; Murcia, Mario; Íñiguez, Carmen; Roca, Marta; González, Llúcia; Yusà, Vicent; Rebagliato, Marisa; Ballester, Ferran
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INVESTIGACIONMetadatos
Título
Distributions and determinants of urinary biomarkers of organophosphate pesticide exposure in a prospective Spanish birth cohort studyAutoría
Fecha de publicación
2017Editor
BioMed CentralCita bibliográfica
LLOP, Sabrina; MURCIA, Mario; ÍÑIGUEZ, Carmen; ROCA, Marta; GONZÁLEZ, Llúcia; YUSÀ, Vicent; REBAGLIATO, Marisa; BALLESTER, Ferran. Distributions and determinants of urinary biomarkers of organophosphate pesticide exposure in a prospective Spanish birth cohort study. Environmental Health (2017), v. 46, issue 16, pp.1-15Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background:
Prenatal exposure to organophosphate pesticides (OPs) has been associated with impaired child
development. Pesticide exposure determinants need to be studied in order to identify sources and pathways ... [+]
Background:
Prenatal exposure to organophosphate pesticides (OPs) has been associated with impaired child
development. Pesticide exposure determinants need to be studied in order to identify sources and pathways of
pesticide exposure. The aim of this paper is to describe prenatal exposure to OPs and evaluate the associated
factors in pregnant women.
Methods:
The study population consisted of pregnant women (
n
= 573) who participated in the INMA birth cohort
study in Valencia (Spain, 2003
–
2006). OP metabolites were analyzed in maternal urine at the 32nd week of gestation
using a liquid chromatography-high resolution mass spectrometry method. The analysis included non-specific (diethyl
phosphate [DEP], diethyl thiophosphate [DETP], dimethyl thiophosphate [DMTP], dimethyl dithiophosphate [DMDTP])
and specific metabolites (2-diethylamino-6-methyl-4-pyrimidinol [DEAMPY], 2-isopropyl-4-methyl-6-hydroxypyrimidine
[IMPY], para-nitrophenol [PNP], and 3,5,6-trichloro-2-pyridinol [TCPY]). Information about the sociodemographic,
environmental, and dietary characteristics was obtained by questionnaire. The association between log-transformed
OPs and covariates was analyzed using multivariable interval censored regression.
Results:
The detection frequencies were low, DMTP and TCPY being the most frequently detected metabolites (53.8%
and 39.1%, respectively). All the OP metabolites were positive
ly associated with maternal intake of fruits and vegetables.
Other maternal characteristics related to the OPs were body mass index (BMI) before pregnancy and smoking habit
during pregnancy. Women with lower BMI and those who did not smoke presented higher OP concentrations. Moreover,
mothers who had a yard or garden with plants at home or who lived in an urban area were also more exposed to OPs.
Conclusions:
The OP detection frequencies and the concentrations observed in our study population were low, compared
with most of the previously published studies. Given the high vulnerability of the fet
us to neurotoxicant exposure, further
research on the determinants of the body
burdenofOPsduringpregnancywouldbenecessary.The knowledge gained from
such studies would enhance the effectiveness of public health control and future recommendations in order to reduce the
risk to both the health of pregnant women and the health and development of their children. [-]
Publicado en
Environmental Health (2017), v. 46, issue 16Derechos de acceso
info:eu-repo/semantics/openAccess
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- MED_Articles [671]
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