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dc.contributor.authorGil Solsona, Ruben
dc.contributor.authorNácher Mestre, Jaime
dc.contributor.authorLacalle-Bergeron, Leticia
dc.contributor.authorVicente Sancho, Juan
dc.contributor.authorCalduch-Giner, Josep
dc.contributor.authorHernandez, Felix
dc.contributor.authorPérez Sánchez, Jaume
dc.date.accessioned2017-06-12T11:37:03Z
dc.date.available2017-06-12T11:37:03Z
dc.date.issued2017
dc.identifier.citationGil-Solsona R, Nácher-Mestre J, Lacalle-Bergeron L, Sancho JV, Calduch-Giner JA, Hernández F, Pérez-Sánchez J. (2017) Untargeted metabolomics approach for unraveling robust biomarkers of nutritional status in fasted gilthead sea bream (Sparus aurata) PeerJ 5:e2920 https://doi.org/10.7717/peerj.2920ca_CA
dc.identifier.issn2167-8359
dc.identifier.urihttp://hdl.handle.net/10234/167957
dc.description.abstractA metabolomic study has been performed to identify sensitive and robust biomarkers of malnutrition in farmed fish, using gilthead sea bream (Sparus aurata) as a model. The metabolomic fingerprinting of serum from fasted fish was assessed by means of ultra-high performance liquid chromatography coupled to quadrupole time-offlight mass spectrometry. More than 15,000 different m/z ions were detected and Partial Least Squares–Discriminant analysis allowed a clear differentiation between the two experimental groups (fed and 10-day fasted fish) with more than 90% of total variance explained by the two first components. The most significant metabolites (up to 45) were elucidated on the basis of their tandem mass spectra with a broad representation of amino acids, oligopeptides, urea cycle metabolites, L-carnitinerelated metabolites, glutathione-related metabolites, fatty acids, lysophosphatidic acids, phosphatidylcholines as well as biotin- and noradrenaline-related metabolites. This untargeted approach highlighted important adaptive responses in energy and oxidative metabolism, contributing to identify robust and nutritionally-regulated biomarkers of health and metabolic condition that will serve to assess the welfare status of farmed fish.ca_CA
dc.description.sponsorShipThis work was supported by the Spanish MINECO (MI2-Fish, AGL2013-48560) and Plà de promoció de la investigació de la Universitat Jaume I (P1•1B2015-59) and the Generalitat Valenciana as research group of excellence (PROMETEO II/2014/023, PROMETEO II/2014/085, Collaborative Research on Environment and Food-Safety, ISIC/2012/016).ca_CA
dc.format.extent19 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherPeerJca_CA
dc.relation.isPartOfPeerJ. 2017; 5: e2920.ca_CA
dc.rightsCopyright 2017 Gil-Solsona et al. Distributed under Creative Commons CC-BY 4.0ca_CA
dc.rightsAtribución 4.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.subjectAquacultureca_CA
dc.subjectNutritionca_CA
dc.subjectChromatographyca_CA
dc.subjectMass spectrometryca_CA
dc.subjectGilthead sea breamca_CA
dc.subjectSerum metabolomicsca_CA
dc.titleUntargeted metabolomics approach for unraveling robust biomarkers of nutritional status in fasted gilthead sea bream (Sparus aurata)ca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.7717/peerj.2920
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://peerj.com/articles/2920/ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersion


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Copyright
2017 Gil-Solsona et al.
Distributed under
Creative Commons CC-BY 4.0
Excepto si se señala otra cosa, la licencia del ítem se describe como: Copyright 2017 Gil-Solsona et al. Distributed under Creative Commons CC-BY 4.0