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Untargeted metabolomics approach for unraveling robust biomarkers of nutritional status in fasted gilthead sea bream (Sparus aurata)
dc.contributor.author | Gil Solsona, Ruben | |
dc.contributor.author | Nácher Mestre, Jaime | |
dc.contributor.author | Lacalle-Bergeron, Leticia | |
dc.contributor.author | Vicente Sancho, Juan | |
dc.contributor.author | Calduch-Giner, Josep | |
dc.contributor.author | Hernandez, Felix | |
dc.contributor.author | Pérez Sánchez, Jaume | |
dc.date.accessioned | 2017-06-12T11:37:03Z | |
dc.date.available | 2017-06-12T11:37:03Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Gil-Solsona R, Nácher-Mestre J, Lacalle-Bergeron L, Sancho JV, Calduch-Giner JA, Hernández F, Pérez-Sánchez J. (2017) Untargeted metabolomics approach for unraveling robust biomarkers of nutritional status in fasted gilthead sea bream (Sparus aurata) PeerJ 5:e2920 https://doi.org/10.7717/peerj.2920 | ca_CA |
dc.identifier.issn | 2167-8359 | |
dc.identifier.uri | http://hdl.handle.net/10234/167957 | |
dc.description.abstract | A metabolomic study has been performed to identify sensitive and robust biomarkers of malnutrition in farmed fish, using gilthead sea bream (Sparus aurata) as a model. The metabolomic fingerprinting of serum from fasted fish was assessed by means of ultra-high performance liquid chromatography coupled to quadrupole time-offlight mass spectrometry. More than 15,000 different m/z ions were detected and Partial Least Squares–Discriminant analysis allowed a clear differentiation between the two experimental groups (fed and 10-day fasted fish) with more than 90% of total variance explained by the two first components. The most significant metabolites (up to 45) were elucidated on the basis of their tandem mass spectra with a broad representation of amino acids, oligopeptides, urea cycle metabolites, L-carnitinerelated metabolites, glutathione-related metabolites, fatty acids, lysophosphatidic acids, phosphatidylcholines as well as biotin- and noradrenaline-related metabolites. This untargeted approach highlighted important adaptive responses in energy and oxidative metabolism, contributing to identify robust and nutritionally-regulated biomarkers of health and metabolic condition that will serve to assess the welfare status of farmed fish. | ca_CA |
dc.description.sponsorShip | This work was supported by the Spanish MINECO (MI2-Fish, AGL2013-48560) and Plà de promoció de la investigació de la Universitat Jaume I (P1•1B2015-59) and the Generalitat Valenciana as research group of excellence (PROMETEO II/2014/023, PROMETEO II/2014/085, Collaborative Research on Environment and Food-Safety, ISIC/2012/016). | ca_CA |
dc.format.extent | 19 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | PeerJ | ca_CA |
dc.relation.isPartOf | PeerJ. 2017; 5: e2920. | ca_CA |
dc.rights | Copyright 2017 Gil-Solsona et al. Distributed under Creative Commons CC-BY 4.0 | ca_CA |
dc.rights | Atribución 4.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | Aquaculture | ca_CA |
dc.subject | Nutrition | ca_CA |
dc.subject | Chromatography | ca_CA |
dc.subject | Mass spectrometry | ca_CA |
dc.subject | Gilthead sea bream | ca_CA |
dc.subject | Serum metabolomics | ca_CA |
dc.title | Untargeted metabolomics approach for unraveling robust biomarkers of nutritional status in fasted gilthead sea bream (Sparus aurata) | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.7717/peerj.2920 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://peerj.com/articles/2920/ | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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