A genome-wide association study of attention function in a population-based sample of children
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Otros documentos de la autoría: Alemany, Silvia; Vilor-Tejedor, Natalia; Bustamante, Mariona; Pujol, Jesús; Macià, Dídac; Martínez Vilavella, Gerard; Fenoll, Raquel; Alvárez-Pedrerol, Mar; Forns, Joan; Julvez, Jordi; Suades-González, Elisabet; Llop, Sabrina; Rebagliato, Marisa; Sunyer Deu, Jordi
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Título
A genome-wide association study of attention function in a population-based sample of childrenAutoría
Fecha de publicación
2016Editor
Public Library of ScienceISSN
1932-6203Cita bibliográfica
Alemany S, Vilor-Tejedor N, Bustamante M, Pujol J, Macià D, Martı´nez-Vilavella G, et al. (2016) A Genome-Wide Association Study of Attention Function in a Population-Based Sample of Children. PLoS ONE 11(9): e0163048. doi:10.1371/journal.pone.0163048Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163048Resumen
Background
Attention function filters and selects behaviorally relevant information. This capacity is
impaired in some psychiatric disorders and has been proposed as an endophenotype for
Attention-Deficit/Hyperac ... [+]
Background
Attention function filters and selects behaviorally relevant information. This capacity is
impaired in some psychiatric disorders and has been proposed as an endophenotype for
Attention-Deficit/Hyperactivity Disorder; however, its genetic basis remains largely
unknown. This study aimed to identify single nucleotide polymorphism (SNPs) associated
with attention function.
Materials and Methods
The discovery sample included 1655 children (7–12 years) and the replication sample
included 546 children (5–8 years). Five attention outcomes were assessed using the computerized
Attentional Network Test (ANT): alerting, orienting, executive attention, Hit Reaction
time (HRT) and the standard error of HRT (HRTSE). A Genome-wide Association
Study was conducted for each outcome. Gene set enrichment analyses were performed to
detect biological pathways associated with attention outcomes. Additional neuroimaging
analyses were conducted to test neural effects of detected SNPs of interest.
Results
Thirteen loci showed suggestive evidence of association with attention function (P<10−5
) in
the discovery sample. One of them, the rs4321351 located in the PID1 gene, was nominally significant in the replication sample although it did not survive multiple testing correction.
Neuroimaging analysis revealed a significant association between this SNP and brain
structure and function involving the frontal-basal ganglia circuits. The mTOR signaling and
Alzheimer disease-amyloid secretase pathways were significantly enriched for alerting, orienting
and HRT respectively (FDR<5%).
Conclusion
These results suggest for the first time the involvement of the PID1 gene, mTOR signaling
and Alzheimer disease-amyloid secretase pathways, in attention function during childhood.
These genes and pathways have been proposed to play a role in neuronal plasticity, memory
and neurodegenerative disease. [-]
Publicado en
PLoS ONE, September 22, 2016Derechos de acceso
info:eu-repo/semantics/openAccess
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- MED_Articles [671]
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