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dc.contributor.authorGracia Lor, Emma
dc.contributor.authorCastiglioni, Sara
dc.contributor.authorBade, Richard
dc.contributor.authorBeen, Frederic
dc.contributor.authorCastrignanò, Erika
dc.contributor.authorCovaci, Adrian
dc.contributor.authorGonzález Mariño, Iria
dc.contributor.authorHapeshi, Evroula
dc.contributor.authorKasprzyk-Hordern, Barbara
dc.contributor.authorKinyua, Juliet
dc.contributor.authorLai, Foon Yin
dc.contributor.authorLetzel, Thomas
dc.contributor.authorLopardo, Luigi
dc.contributor.authorMeyer, Markus R.
dc.contributor.authorO'Brien, Jake
dc.contributor.authorRamin, Pedram
dc.contributor.authorRousis, Nikolaos I
dc.contributor.authorRydevik, Axel
dc.contributor.authorRyu, Yeonsuk
dc.contributor.authorSantos, Miguel M.
dc.contributor.authorSenta, Ivan
dc.contributor.authorThomaidis, Nikolaos
dc.contributor.authorVeloutsou, Sofia
dc.contributor.authorYang, Zhugen
dc.contributor.authorZuccato, Ettore
dc.contributor.authorBijlsma, Lubertus
dc.date.accessioned2017-01-31T10:27:51Z
dc.date.available2017-01-31T10:27:51Z
dc.date.issued2017-02
dc.identifier.citationGRACIA-LOR, Emma, et al. Measuring biomarkers in wastewater as a new source of epidemiological information: Current state and future perspectives. Environment International, 2016.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/165745
dc.description.abstractThe information obtained from the chemical analysis of specific human excretion products (biomarkers) in urban wastewater can be used to estimate the exposure or consumption of the population under investigation to a defined substance. A proper biomarker can provide relevant information about lifestyle habits, health and wellbeing, but its selection is not an easy task as it should fulfil several specific requirements in order to be successfully employed. This paper aims to summarize the current knowledge related to the most relevant biomarkers used so far. In addition, some potential wastewater biomarkers that could be used for future applications were evaluated. For this purpose, representative chemical classes have been chosen and grouped in four main categories: (i) those that provide estimates of lifestyle factors and substance use, (ii) those used to estimate the exposure to toxicants present in the environment and food, (iii) those that have the potential to provide information about public health and illness and (iv) those used to estimate the population size. To facilitate the evaluation of the eligibility of a compound as a biomarker, information, when available, on stability in urine and wastewater and pharmacokinetic data (i.e. metabolism and urinary excretion profile) has been reviewed. Finally, several needs and recommendations for future research are proposed.ca_CA
dc.description.sponsorShipThis work was supported by the COST Action ES1307 “SCORE – Sewage biomarker analysis for community health assessment”. Emma Gracia-Lor is very grateful to Generalitat Valenciana, Conselleria d'Educació, Investigació, Cultura i Esport (APOSTD/2015, Programa VALi + d) for her post-doctoral contract. Lubertus Bijlsma acknowledges NPS-Euronet (HOME/2014/JDRUG/AG/DRUG/7086), co-funded by the European Union, for his post-doctoral fellowship. Erika Castrignanò, Richard Bade, Juliet Kinyua, Pedram Ramin, Nikolaos I. Rousis, Yeonsuk Ryu would like to thank the SEWPROF MC ITN project, ‘A new paradigm in drug use and human health risk assessment: Sewage profiling at the community level’ [grant agreement 317205] supported by the European Union's Seventh Framework Programme for research, technological development and demonstration for the financial support. Iria González-Mariño extends her gratitude to the Galician Council of Culture, Education and Universities for her postdoctoral contract (Plan Galego de Investigación, Innovación e Crecemento 2011–2015). Foon Yin Lai acknowledges her postdoctoral fellowship from the University of Antwerp. Luigi Lopardo, Axel Rydevik and Barbara Kasprzyk-Hordern would like to acknowledge Leverhulme Trust for funding ‘TOX-EDC, Wastewater profiling for community-wide human exposure assessment from environmental endocrine disrupting chemicals in personal care and consumer products’ (Project No: RPG-2013-297). Frederic Been would like to thank the Swiss National Science Foundation (SNF, P2LAP2_164892) for his post-doctoral grant. This publication reflects the views only of the authors, and the European Commission cannot be held responsible for any use which may be made of the information contained therein.ca_CA
dc.format.extent19 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfEnvironment International Volume 99, February 2017ca_CA
dc.rights© 2016 Elsevier Ltd. All rights reserved.ca_CA
dc.subjectWastewaterca_CA
dc.subjectEpidemiologyca_CA
dc.subjectBiomarkerca_CA
dc.subjectConsumptionca_CA
dc.subjectExposureca_CA
dc.subjectPopulationca_CA
dc.titleMeasuring biomarkers in wastewater as a new source of epidemiological information: current state and future perspectivesca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.envint.2016.12.016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0160412016306936ca_CA


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