Determination of pharmaceutical compounds in water samples by solid phase extraction and liquid chromatography with photodiode array detector
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Título
Determination of pharmaceutical compounds in water samples by solid phase extraction and liquid chromatography with photodiode array detectorAutoría
Tutor/Supervisor
Pitarch Arquimbau, María Elena; Universitat Jaume I. Departament de Química Física i AnalíticaFecha de publicación
2015-07-24Editor
Universitat Jaume IResumen
In the present work, an analytical method for the simultaneous determination of
four pharmaceutical compounds (carbamazepine, ketoprofen, naproxen and
diclofenac), in water samples, was developed. The method involves ... [+]
In the present work, an analytical method for the simultaneous determination of
four pharmaceutical compounds (carbamazepine, ketoprofen, naproxen and
diclofenac), in water samples, was developed. The method involves sample treatment
by solid phase extraction (SPE) using Oasis HLB cartridges and subsequent
determination by high-performance liquid chromatography (HPLC) with photodiode
array detector (PDA). SPE was optimized basis on three different elution solvents.
Method was validated at three concentration levels (0,2 ng/mL, 2 ng/mL and 10
ng/mL) obtaining adequate results only for carbamazepine and naproxen. LC-PDA
methodology developed was applied to the analysis of surface water coming from
Millars River (Almassora, Castelló, Spain) and four treatment plants sited in Castelló
province. None of pharmaceutical studied could be detected by LC-PDA. An
alternative and sensitive method carried out by HPLC coupled to tandem mass
spectrometry (MS/MS) confirmed the presence of several pharmaceuticals at low
concentrations levels (below 1 ng/mL). [-]
Palabras clave / Materias
Descripción
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic 2014-2015
Tipo de documento
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- Grau en Química [265]