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The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulin

dc.contributor.authorTorijano Gutiérrez, Sandra Adela
dc.contributor.authorVilanova Gallén, Concepción
dc.contributor.authorDiaz-Oltra, Santiago
dc.contributor.authorMurga, Juan
dc.contributor.authorFalomir, Eva
dc.contributor.authorCarda, Miguel
dc.contributor.authorRedondo Horcajo, Mariano
dc.contributor.authorFernando Díaz, J.
dc.contributor.authorBarasoain, Isabel
dc.contributor.authorMarco, J. Alberto
dc.date.accessioned2016-02-08T08:14:10Z
dc.date.available2016-02-08T08:14:10Z
dc.date.issued2015-06-17
dc.identifier.citationTORIJANO‐GUTIÉRREZ, Sandra, et al. The Mechanism of the Interactions of Pironetin Analog/Combretastatin A‐4 Hybrids with Tubulin. Archiv der Pharmazie, 2015, vol. 348, no 8, p. 541-547.ca_CA
dc.identifier.issn0365-6233
dc.identifier.urihttp://hdl.handle.net/10234/148845
dc.description.abstractWe here report an investigation of the interactions with tubulin of two types of molecules of a hybrid structural type consisting in a combretastatin A-4 moiety and a simplified pironetin fragment. The cytotoxicities of the molecules on two reference tumoral cell lines were measured. In addition, the effects of the compounds on the cell cycle and on microtubule assembly were observed. The dynamics of microtubule polymerization was investigated by means of immunofluorescence assays. It was thus established that at least some of the compounds under study exert their cytotoxic action by means of interaction with tubulin.ca_CA
dc.description.sponsorShipFinancial support to the research has been granted by the Spanish Government (MINECO, Ministerio de Economía y Competitividad, research grants CTQ2008-02800 and CTQ2011-27560), by the Consellería d'Empresa, Universitat i Ciencia de la Generalitat Valenciana (research grants PROMETEO/2013/027, ACOMP09/113 and ACOMP/2014/272) and by the Universitat Jaume I (research grants P1-1B-2008-14 and PI-1B-2011-37). C.V. thanks the MINECO for a predoctoral fellowship of the FPI program. Part of the biological work has been supported by the BIPPED2 (grant S2010/BMD-2457 to J.F.D.), by the Comunidad de Madrid and by the MINECO (grant BIO2013-42984-R) to J.F.D. We further thank Prof. C. M. Cerda García-Rojas, from the Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico, for the kind sending of pironetin samples; P. Lastres for his help with flow cytometry; and the Matadero Municipal Vicente de Lucas in Segovia for providing the calf brains which were the source of tubulinca_CA
dc.format.extent7 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherWileyca_CA
dc.relation.isPartOfArchiv der Pharmazie, 2015, vol. 348, no 8ca_CA
dc.rights© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectCombretastatin A-4 derivativesca_CA
dc.subjectCytotoxic compoundsca_CA
dc.subjectHybrid moleculesca_CA
dc.subjectMicrotubulesca_CA
dc.subjectPironetinca_CA
dc.titleThe Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulinca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1002/ardp.201500106
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://onlinelibrary.wiley.com/doi/10.1002/ardp.201500106/fullca_CA


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