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Centrally formed acetaldehyde mediates ethanol-induced brain PKA activation
dc.contributor.author | Tarragon Cros, Ernesto | |
dc.contributor.author | Baliño, Pablo | |
dc.contributor.author | González Aragón, Carlos Manuel | |
dc.date.accessioned | 2015-07-15T09:34:51Z | |
dc.date.available | 2015-07-15T09:34:51Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | TARRAGON, E.; BALIÑO, P.; GONZÁLEZ ARAGÓN, C. M. Centrally formed acetaldehyde mediates ethanol-induced brain PKA activation. Neuroscience letters, 2014, vol. 580, p. 68-73. | ca_CA |
dc.identifier.issn | 0304-3940 | |
dc.identifier.issn | 1872-7972 | |
dc.identifier.uri | http://hdl.handle.net/10234/127657 | |
dc.description.abstract | Centrally formed acetaldehyde has proven to be responsible for several psychopharmacological effects induced by ethanol. In addition, it has been suggested that the cAMP-PKA signaling transduction pathway plays an important role in the modulation of several ethanol-induced behaviors. Therefore, we hypothesized that acetaldehyde might be ultimately responsible for the activation of this intracellular pathway. We used three pharmacological agents that modify acetaldehyde activity (α-lipoic acid, aminotriazole, and d-penicillamine) to study the role of this metabolite on EtOH-induced PKA activation in mice. Our results show that the injection of α-lipoic acid, aminotriazole and d-penicillamine prior to acute EtOH administration effectively blocks the PKA-enhanced response to EtOH in the brain. These results strongly support the hypothesis of a selective release of acetaldehyde-dependent Ca2+ as the mechanism involved in the neurobehavioral effects elicited by EtOH. | ca_CA |
dc.description.sponsorShip | This research was supported by a grant from the Spanish Ministerio de Ciencia e Innovacion (PSI2011-28934/PSIC). Pablo Baliño was supported by a fellowship from the CICYT (BES-2009-024438). Ernesto Tarragon was supported at the time by Red de Trastornos Adictivos, Ministerio de Sanidad y Politica Social (RD06/0001/0028), Spain. | ca_CA |
dc.format.extent | 6 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isFormatOf | entrally formed acetaldehyde mediates ethanol-induced brain PKA activation. Neuroscience letters, 2014, vol. 580, p. 68-73 | ca_CA |
dc.relation.isPartOf | Neuroscience letters, 2014, vol. 580 | ca_CA |
dc.rights | Copyright © 2015 Elsevier B.V. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | acetaldehyde | ca_CA |
dc.subject | PKA | ca_CA |
dc.subject | ethanol | ca_CA |
dc.title | Centrally formed acetaldehyde mediates ethanol-induced brain PKA activation | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.neulet.2014.07.046 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0304394014006272 | ca_CA |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
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