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Tetrapeptidic Molecular Hydrogels: Self-assembly and Co-aggregation with Amyloid Fragment Aβ1-40
dc.contributor.author | Tena Solsona, Marta | |
dc.contributor.author | Miravet, Juan | |
dc.contributor.author | Escuder, Beatriu | |
dc.date.accessioned | 2015-06-30T11:43:23Z | |
dc.date.available | 2015-06-30T11:43:23Z | |
dc.date.issued | 2014-01 | |
dc.identifier.issn | 0947-6539 | |
dc.identifier.issn | 1521-3765 | |
dc.identifier.uri | http://hdl.handle.net/10234/125414 | |
dc.description.abstract | A new family of isomeric tetrapeptides containing aromatic and polar amino acid residues that are able to form molecular hydrogels following a smooth change in pH is described. The hydrogels have been studied by spectroscopic and microscopic techniques showing that the peptide primary sequence has an enormous influence on the self-assembly process. In particular, the formation of extended hydrophobic regions and the appearance of π-stacking interactions have been revealed as the driving forces for aggregation. Moreover, the interaction of these compounds with amyloid peptidic fragment Aβ1-40 has been studied and some of them have been shown to act as templates for the aggregation of this peptide into non-β-sheet fibrillar structures. These compounds could potentially be used for the capture of toxic, soluble amyloid oligomers. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | WILEY-VCH Verlag GmbH & Co. KGaA | ca_CA |
dc.relation.isPartOf | Chemistry - A European Journal Vol. 20, no. 4, 2014 | ca_CA |
dc.rights | Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | aggregation | ca_CA |
dc.subject | fibers | ca_CA |
dc.subject | gels | ca_CA |
dc.subject | peptides | ca_CA |
dc.subject | self-assembly | ca_CA |
dc.title | Tetrapeptidic Molecular Hydrogels: Self-assembly and Co-aggregation with Amyloid Fragment Aβ1-40 | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1002/chem.201400346 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://onlinelibrary.wiley.com/doi/10.1002/chem.201302651/full | ca_CA |
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