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dc.contributor.authorRuiz Ángel, M. J.
dc.contributor.authorGarcía Álvarez-Coque, M. C.
dc.contributor.authorBerthod, A.
dc.contributor.authorCarda-Broch, Samuel
dc.date.accessioned2015-06-22T08:49:29Z
dc.date.available2015-06-22T08:49:29Z
dc.date.issued2015-06-22
dc.identifier.issn0021-9673
dc.identifier.urihttp://hdl.handle.net/10234/124563
dc.description.abstractMethod validation is being applied in the reported analytical methods for decades. Even before this protocol was defined, authors already somehow validated their methods without full awareness. They wished to assure the quality of their work. Validation is an applied approach to verify that a method is suitable and rugged enough to function as a quality control tool in different locations and times. The performance parameters and statistical protocols followed throughout a validation study vary with the source of guidelines. Before single laboratory validation, an analytical method should be fully developed and optimized. The purpose of the validation is to confirm performance parameters that are determined during method development, and it should provide information on how the method will perform under routine use. An unstable method may require re-validation. Further method development and optimization will be needed if validation results do not meet the accepted performance standards. When possible, the validation protocol should also be conducted as a collaborative study by multiple laboratories, on different instruments, reagents, and standards. At this point, it would be interesting to know how people are validating their methods. Are they evaluating all defined validation parameters? Are they indicating the followed guidelines? Is re-validation really currently used? Is validation performed by a single laboratory, or is it a collaborative work by several laboratories? Is it an evolving discipline? In this survey, we will try to answer these questions focused to the field of liquid chromatography.ca_CA
dc.format.extent8 p.ca_CA
dc.language.isoengca_CA
dc.relation.isPartOfJournal of Chromatography A, 2014, 1353: 2-9ca_CA
dc.rightsCopyright © 2014 Elsevier B.V. All rights reserved.ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectMethod validationca_CA
dc.subjectLiquid chromatographyca_CA
dc.subjectSurveyca_CA
dc.subjectGuidelinesca_CA
dc.subjectEvaluated validation parametersca_CA
dc.subjectAnalystsca_CA
dc.titleAre analysts doing method validation in liquid chromatography?ca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doi10.1016/j.chroma.2014.05.052
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0021967314008188ca_CA
dc.editionCopyright © 2014 Elsevier B.V. All rights reserved.ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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