Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies
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Otros documentos de la autoría: Casas, Maribel; Chatzi, Leda; Carsi, Anne-Elie; Amiano, Pilar; Guxens, Mònica; Kogevinas, Manolis; Koutra, Katerina; Lertxundi, Nerea; Murcia, Mario; Rebagliato, Marisa; Riaño, Isolina; Rodríguez-Bernal, Clara L.; Roumeliotaki, Theano; Sunyer Deu, Jordi; Mendez, Michelle; Vrijheid, Martine
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Título
Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studiesAutoría
Fecha de publicación
2013Editor
International Epidemiological Association; Oxford University PressISSN
0300-5771Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://ije.oxfordjournals.org/content/42/2/506.shortVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background Maternal pre-pregnancy obesity may be associated with impaired infant neuropsychological development; however, there are few studies and it is unclear if reported associations are due to intrauterine ... [+]
Background Maternal pre-pregnancy obesity may be associated with impaired infant neuropsychological development; however, there are few studies and it is unclear if reported associations are due to intrauterine mechanisms.
Methods We assessed whether maternal pre-pregnancy overweight and obesity were associated with cognitive and psychomotor development scores (mean 100 ± 15) of children aged 11–22 months in two birth cohorts: Environment and Childhood (INMA, Spain; n = 1967) and Mother-Child (RHEA, Greece: n = 412). Paternal body mass index (BMI) was used as a negative control exposure.
Results The percentage of overweight and obese mothers was 18% and 8%, respectively, in INMA and 20% and 11% in RHEA, respectively. Maternal pre-pregnancy obesity was associated with reduced infant cognitive development scores in both INMA (score reduction: −2.72; 95% CI: −5.35, −0.10) and RHEA (score reduction: −3.71; 95% CI: −8.45, 1.02), after adjusting for socioeconomic variables and paternal BMI. There was evidence in both cohorts of a dose-response relationship with continuous maternal BMI. Paternal overweight/obesity was not associated with infant cognitive development. Associations with psychomotor scores were not consistent between cohorts, and were stronger for paternal than maternal BMI in RHEA.
Conclusions This study in two birth cohorts with moderately high obesity prevalence suggests that maternal pre-pregnancy obesity is associated with reduced child cognitive development at early ages. This association appears more likely to be due to maternal than shared family and social mechanisms, but further research is needed to disentangle a direct intrauterine effect from other maternal confounding factors. [-]
Publicado en
International Journal of Epidemiology, vol. 42 (2), p. 506-517Derechos de acceso
© The Author 2013; all rights reserved.
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