Listar por tema "acetaldehyde"
Mostrando ítems 1-6 de 6
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Centrally formed acetaldehyde mediates ethanol-induced brain PKA activation
Elsevier (2014)Centrally formed acetaldehyde has proven to be responsible for several psychopharmacological effects induced by ethanol. In addition, it has been suggested that the cAMP-PKA signaling transduction pathway plays an important ... -
Effects of Acute Ethanol Administration on Brain Oxidative Status: The Role of Acetaldehyde
Wiley (2019-08)Background: Ethanol (EtOH), one of the most widely consumed substances of abuse, can induce brain damage and neurodegeneration. EtOH is centrally metabolized into acetaldehyde, which has been shown to be responsible for ... -
La Inducción del citocromo P450 2E1 en el cerebro aumenta la actividad locomotora producida por el etanol en ratones
Universitat Jaume I (2014-06-16)In the central nervous system ethanol (EtOH) is metabolized into acetaldehyde by different enzymes. Brain catalase accounts for 60% of the total production of ETOH-derived acetaldehyde, whereas cerebral cytochrome P450 ... -
Induction of brain cytochrome P450 2E1 boosts the locomotor-stimulating effects of ethanol in mice
Elsevier (2014)In the central nervous system ethanol (EtOH) is metabolized into acetaldehyde by different enzymes. Brain catalase accounts for 60% of the total production of EtOH-derived acetaldehyde, whereas cerebral cytochrome P450 2E1 ... -
Involvement of the endogenous opioid system in the psychopharmacological actions of ethanol: the role of acetaldehyde
Frontiers Media (2013)Significant evidence implicates the endogenous opioid system (EOS) (opioid peptides and receptors) in the mechanisms underlying the psychopharmacological effects of ethanol. Ethanol modulates opioidergic signaling and ... -
The rostromedial tegmental nucleus RMTg is not a critical site for ethanol-induced motor activation in rats
Springer Nature (2023-07-20)-Rationale : Opioid drugs indirectly activate dopamine (DA) neurons in the ventral tegmental area (VTA) through a disinhibition mechanism mediated by mu opioid receptors (MORs) present both on the GABA projection neurons ...